Abstract
1. Systolic time intervals (STI) were recorded in six normal male subjects over a period of 3 weeks. On one day per week, each subject received incremental doses of atropine intravenously to increase heart rate, allowing the determination of individual STI v HR regression equations. On the other days STI were recorded with the subjects resting, in the supine position. 2. There were highly significant regression relationships between heart rate and both LVET and QS2, but not between heart rate and PEP. 3. The regression relationships showed little intra-subject variability, but a large degree of inter-subject variability: they proved adequate to correct the STI for the daily fluctuations in heart rate. 4. Administration of small doses of atropine intravenously provides a satisfactory and convenient method of deriving individual STI v HR regression equations which can be applied over a period of weeks.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Burgess C. D., Wadsworth J., Warrington S. J. Evaluation of some non-invasive indices of cardiovascular function [proceedings]. Br J Clin Pharmacol. 1979 Apr;7(4):436P–437P. doi: 10.1111/j.1365-2125.1979.tb00980.x. [DOI] [PubMed] [Google Scholar]
- Carliner N. H., Gilbert C. A., Pruitt A. W., Goldberg L. I. Effects of maintenance digoxin therapy on systolic time intervals and serum digoxin concentrations. Circulation. 1974 Jul;50(1):94–98. doi: 10.1161/01.cir.50.1.94. [DOI] [PubMed] [Google Scholar]
- Das G. P., Talmers R. N., Weissler A. M. Comparative pharmacodynamics of betamethyl digoxin and digoxin in man. Clin Pharmacol Ther. 1977 Sep;22(3):280–285. doi: 10.1002/cpt1977223280. [DOI] [PubMed] [Google Scholar]
- Hinderling P. H., Garrett E. R. Pharmacokinetics of beta-methyldigoxin in healthy humans III: Pharmacodynamic correlations. J Pharm Sci. 1977 Mar;66(3):326–329. doi: 10.1002/jps.2600660305. [DOI] [PubMed] [Google Scholar]
- Kelman A. W., Sumner D. J., Lonsdale M., Lawrence J. R., Whiting B. Comparative pharmacokinetics and pharmacodynamics of cardiac glycosides. Br J Clin Pharmacol. 1980 Aug;10(2):135–143. doi: 10.1111/j.1365-2125.1980.tb01730.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sykes C. A., Wright A. D., Malins J. M., Pentecost B. L. Changes in systolic time intervals during treatment of diabetes mellitus. Br Heart J. 1977 Mar;39(3):255–259. doi: 10.1136/hrt.39.3.255. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Van Der Hoeven G. M., Clerens P. J., Donders J. J., Beneken J. E., Vonk J. T. A study of systolic time intervals during uninterrupted exercise. Br Heart J. 1977 Mar;39(3):242–254. doi: 10.1136/hrt.39.3.242. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Waagstein F., Hjalmarson A. C., Wasir H. S. Apex cardiogram and systolic time intervals in acute myocardial infarction and effects of practolol. Br Heart J. 1974 Nov;36(11):1109–1121. doi: 10.1136/hrt.36.11.1109. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Weissler A. M., Harris W. S., Schoenfeld C. D. Systolic time intervals in heart failure in man. Circulation. 1968 Feb;37(2):149–159. doi: 10.1161/01.cir.37.2.149. [DOI] [PubMed] [Google Scholar]