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. 1981 Sep;12(3):319–325. doi: 10.1111/j.1365-2125.1981.tb01220.x

Direct measurement of chlormethiazole extraction by liver, lung and kidney in man.

L E Mather, W B Runciman, A H Ilsley, K R Thomson, A R Goldin
PMCID: PMC1401788  PMID: 7295462

Abstract

1 Chlormethiazole was used as a basal sedative for patients undergoing angiographic procedures. 2 Blood samples were drawn opportunistically to examine chlormethiazole extraction across liver, lungs and kidney. 3 Extraction across liver was typically 70-80% and apparently unrelated to input concentrations. Evidence for extraction across lung and kidney was inconclusive but these could each be approximately 20%. 4 Pharmacokinetics of chlormethiazole derived from compartment models were in accord with previous reports and were characterised by a high total body clearance (1-1.5 l/min). 5 Postural changes associated with the radiological procedures caused fluctuating blood concentrations which appear as noise in curve fitting procedures. 6 Pharmacokinetic properties derived from compartment theory cannot cope with these perturbations because of the restriction imposed by time averaging (i.e. mean clearances, half-lives and volumes are produced). Systematic studies of pharmacokinetic properties of perfusion-limited drugs such as chlormethiazole must be developed in such a way as to allow for independent variation of flow and extraction.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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