Abstract
1 The effect of a single oral dose of labetalol (100 mg), propranolol (80 mg) and placebo on the pressor response to sexual autostimulation has been studied in six female volunteers. 2 Labetalol but not propranolol significantly reduced the increase in blood pressure that occurred at orgasm. 3 The subjective features of the sexual response were assessed by each subject using visual analogue scales. 4 Subjects reported a significant reduction in vaginal lubrication with labetalol compared to both placebo and propranolol. 5 No other effects were noted.
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Selected References
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- Edwards R. C., Raftery E. B. Haemodynamic effects of long-term oral labetalol. Br J Clin Pharmacol. 1976 Aug;3(4 Suppl 3):733–736. [PubMed] [Google Scholar]
- Fox C. A., Fox B. Blood pressure and respiratory patterns during human coitus. J Reprod Fertil. 1969 Aug;19(3):405–415. doi: 10.1530/jrf.0.0190405. [DOI] [PubMed] [Google Scholar]
- Fox C. A. Reduction in the rise of systolic blood pressure during human coitus by the beta-adrenergic blocking agent, propranolol. J Reprod Fertil. 1970 Aug;22(3):587–590. doi: 10.1530/jrf.0.0220587. [DOI] [PubMed] [Google Scholar]
- Littler W. A., Honour A. J., Sleight P. Direct arterial pressure, heart rate and electrocardiogram during human coitus. J Reprod Fertil. 1974 Oct;40(2):321–331. doi: 10.1530/jrf.0.0400321. [DOI] [PubMed] [Google Scholar]
- Maconochie J. G., Richards D. A., Woodings E. P. Modification of pressor responses induced by 'cold' [proceedings]. Br J Clin Pharmacol. 1977 Jun;4(3):389P–389P. [PubMed] [Google Scholar]
- Richards D. A., Prichard B. N., Dobbs R. J. Adrenoceptor blockade of the circulatory responses to intravenous isoproterenol. Clin Pharmacol Ther. 1978 Sep;24(3):264–273. doi: 10.1002/cpt1978243264. [DOI] [PubMed] [Google Scholar]
- Richards D. A., Prichard B. N., Hernández R. Circulatory effects of noradrenaline and adrenaline before and after labetalol. Br J Clin Pharmacol. 1979 Apr;7(4):371–378. [PMC free article] [PubMed] [Google Scholar]
- Wiedeking C., Lake C. R., Ziegler M., Kowarski A. A., Money J. Plasma noradrenaline and dopamine-beta-hydroxylase during sexual activity. Psychosom Med. 1977 Mar-Apr;39(2):143–148. doi: 10.1097/00006842-197703000-00009. [DOI] [PubMed] [Google Scholar]
- Wiedeking C., Ziegler M. G., Lake C. R. Plasma noradrenaline and dopamine-beta-hydroxylase during human sexual activity. J Psychiatr Res. 1979;15(2):139–145. doi: 10.1016/0022-3956(79)90025-6. [DOI] [PubMed] [Google Scholar]