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. 1981 Sep;12(3):387–392. doi: 10.1111/j.1365-2125.1981.tb01231.x

Effect of chronic diuretic treatment on the plasma renin-angiotensin-aldosterone system in essential hypertension.

P Lijnen, R Fagard, J Staessen, A Amery
PMCID: PMC1401821  PMID: 7028060

Abstract

1 Chronic treatment with a constant dose of hydrochlorothiazide or tienilic acid increases plasma renin activity (PRA) acutely to reach a maximum within the first week. 2 During chronic diuretic therapy from 1 month to 1 year, PRA remained elevated at a rather constant level, though this was somewhat lower than the maximum level reached after 1 week. 3 A significant (P less than 0.01) correlation (r = 0.74) between changes in plasma angiotensin II and renin activity provoked by chronic treatment for 3 months with hydrochlorothiazide and tienilic acid was found. 4 The increase in plasma aldosterone during chronic treatment with hydrochlorothiazide and tienilic acid (1000 mg) is related (r = 0.68; P less than 0.01) to the rise in plasma angiotensin II.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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