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. 1981 Aug;12(2):189–193. doi: 10.1111/j.1365-2125.1981.tb01199.x

Radioimmunoassay for trifluoperazine in human plasma.

K K Midha, J W Hubbard, J K Cooper, E M Hawes, S Fournier, P Yeung
PMCID: PMC1401876  PMID: 7306433

Abstract

1 A new sensitive and rapid radioimmunoassay procedure for the determination of the plasma concentrations of the neuroleptic drug trifluoperazine is described. 2 The antiserum developed for trifluoperazine cross-reacted with N-desmethyltrifluoperazine and 7-hydroxytrifluoperazine to the extent of 26 and 24% respectively but its cross-reactivity with commonly co-administered tricyclic antidepressants and antianxiety agents tested was negligible. 3 The assay, based on the above antiserum, enabled the quantitation of 50 pg of the drug in 200 microliters of plasma with a coefficient of variation of about 2% and therefore should be applicable for singly dose pharmacokinetic and bioavailability studies. It should be applicable to therapeutic monitoring of the drug in patients.

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Selected References

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