Skip to main content
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1981 Aug;12(2):97–102. doi: 10.1111/j.1365-2125.1981.tb01186.x

Assessment of urinary 6 beta-hydroxycortisol as an in vivo index of mixed-function oxygenase activity.

B K Park
PMCID: PMC1401879  PMID: 7030374

Full text

PDF
97

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Acocella G., Pagani V., Marchetti M., Baroni G. C., Nicolis F. B. Kinetic studies on rifampicin. I. Serum concentration analysis in subjects treated with different oral doses over a period of two weeks. Chemotherapy. 1971;16(6):356–370. doi: 10.1159/000220750. [DOI] [PubMed] [Google Scholar]
  2. BLEDSOE T., ISLAND D. P., NEY R. L., LIDDLE G. W. AN EFFECT OF O,P'-DDD ON THE EXTRA-ADRENAL METABOLISM OF CORTISOL IN MAN. J Clin Endocrinol Metab. 1964 Dec;24:1303–1311. doi: 10.1210/jcem-24-12-1303. [DOI] [PubMed] [Google Scholar]
  3. BURSTEIN S., DORFMAN R. I., NADEL E. M. 6 beta-Hydroxycortisol--a new steroid in human urine. Arch Biochem Biophys. 1954 Nov;53(1):307–308. doi: 10.1016/0003-9861(54)90254-4. [DOI] [PubMed] [Google Scholar]
  4. BURSTEIN S., KLAIBER E. L. PHENOBARBITAL-INDUCED INCREASE IN 6-BETA-HYDROXYCORTISOL EXCRETION: CLUE TO ITS SIGNIFICANCE IN HUMAN URINE. J Clin Endocrinol Metab. 1965 Feb;25:293–296. doi: 10.1210/jcem-25-2-293. [DOI] [PubMed] [Google Scholar]
  5. Ballinger B., Browning M., O'Malley K., Stevenson I. H. Drug-metabolizing capacity in states of drug dependence and withdrawal. Br J Pharmacol. 1972 Aug;45(4):638–643. doi: 10.1111/j.1476-5381.1972.tb08122.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Berman M. L., Green O. C. Acute stimulation of cortisol metabolism by pentobarbital in man. Anesthesiology. 1971 Apr;34(4):365–369. doi: 10.1097/00000542-197104000-00020. [DOI] [PubMed] [Google Scholar]
  7. Brodie M. J., Boobis A. R., Dollery C. T., Hillyard C. J., Brown D. J., MacIntyre I., Park B. K. Rifampicin and vitamin D metabolism. Clin Pharmacol Ther. 1980 Jun;27(6):810–814. doi: 10.1038/clpt.1980.115. [DOI] [PubMed] [Google Scholar]
  8. Burstein S., Bhavnani B. R. Effect of phenobarbital administration on the in vitro hydroxylation of cortisol and on over-all substrate and product metabolism in the guinea pig and rat. Endocrinology. 1967 Feb;80(2):351–356. doi: 10.1210/endo-80-2-351. [DOI] [PubMed] [Google Scholar]
  9. Burstein S., Kimball H. L., Klaiber E. L., Gut M. Metabolism of 2-alpha- and 6-beta-hydroxycortisol in man: determination of production rates of 6-beta-hydroxycortisol with and without phenobarbital administration. J Clin Endocrinol Metab. 1967 Apr;27(4):491–499. doi: 10.1210/jcem-27-4-491. [DOI] [PubMed] [Google Scholar]
  10. Challiner M. R., Park B. K., Odum J., Orton T. C., Parker G. L. The effects of phenobarbitone on urinary 6 beta-hydroxycortisol excretion and hepatic enzyme activity in the marmoset monkey (Callithrix jacchus). Biochem Pharmacol. 1980 Dec;29(24):3319–3324. doi: 10.1016/0006-2952(80)90310-x. [DOI] [PubMed] [Google Scholar]
  11. Chamberlain J. The determination of urinary 6-oxygenated cortisol in evaluating liver function. Clin Chim Acta. 1971 Sep;34(2):269–271. doi: 10.1016/0009-8981(71)90179-3. [DOI] [PubMed] [Google Scholar]
  12. Conney A. H. Pharmacological implications of microsomal enzyme induction. Pharmacol Rev. 1967 Sep;19(3):317–366. [PubMed] [Google Scholar]
  13. Eade O. E., Maddison A., Leonard P. J., Wright R. Ratio of urinary 6beta-hydroxycortisol to 17-hydroxycorticosteroids in patients with liver disease. Digestion. 1977;16(1-2):169–174. doi: 10.1159/000198068. [DOI] [PubMed] [Google Scholar]
  14. FRANTZ A. G., KATZ F. H., JAILER J. W. 6beta-Hydroxycortisol and other polar corticosteroids: measurement and significance in human urine. J Clin Endocrinol Metab. 1961 Oct;21:1290–1303. doi: 10.1210/jcem-21-10-1290. [DOI] [PubMed] [Google Scholar]
  15. Huffman D. H., Shoeman D. W., Pentikäinen P., Azarnoff D. L. The effect of spironolactone on antipyrine metabolism in man. Pharmacology. 1973;10(6):338–344. doi: 10.1159/000136455. [DOI] [PubMed] [Google Scholar]
  16. Kahn G. C., Boobis A. R., Blair I., Brodie M. J., Davies D. S. Antipyrine as an in vitro probe of mixed function oxidase activity [proceeding]. Br J Clin Pharmacol. 1980 Mar;9(3):284P–284P. doi: 10.1111/j.1365-2125.1980.tb04844.x. [DOI] [PubMed] [Google Scholar]
  17. Kornel L., Miyabo S., Saito Z., Cha R-W, Wu F-T Corticosteroids in human blood. VIII. Cortisol metabolites in plasma of normotensive subjects and patients with essential hypertension. J Clin Endocrinol Metab. 1975 Jun;40(6):949–958. doi: 10.1210/jcem-40-6-949. [DOI] [PubMed] [Google Scholar]
  18. Lai A. A., Levy R. H., Cutler R. E. Time-course of interaction between carbamazepine and clonazepam in normal man. Clin Pharmacol Ther. 1978 Sep;24(3):316–323. doi: 10.1002/cpt1978243316. [DOI] [PubMed] [Google Scholar]
  19. Ohnhaus E. E., Park B. K. Measurement of urinary 6-beta-hydroxycortisol excretion as an in vivo parameter in the clinical assessment of the microsomal enzyme-inducing capacity of antipyrine, phenobarbitone and rifampicin. Eur J Clin Pharmacol. 1979 Mar 26;15(2):139–145. doi: 10.1007/BF00609878. [DOI] [PubMed] [Google Scholar]
  20. Park B. K. A direct radioimmunoassay for 6 beta-hydroxycortisol in human urine. J Steroid Biochem. 1978 Oct;9(10):963–966. doi: 10.1016/0022-4731(78)90058-4. [DOI] [PubMed] [Google Scholar]
  21. Park B. K., Breckenridge A. M. Clinical implications of enzyme induction and enzyme inhibition. Clin Pharmacokinet. 1981 Jan-Feb;6(1):1–24. doi: 10.2165/00003088-198106010-00001. [DOI] [PubMed] [Google Scholar]
  22. Poland A., Smith D., Kuntzman R., Jacobson M., Conney A. H. Effect of intensive occupational exposure to DDT on phenylbutazone and cortisol metabolism in human subjects. Clin Pharmacol Ther. 1970 Sep-Oct;11(5):724–732. doi: 10.1002/cpt1970115724. [DOI] [PubMed] [Google Scholar]
  23. Roots I., Holbe R., Hövermann W., Nigam S., Heinemeyer G., Hildebrandt A. G. Quantitative determination by HPLC of urinary 6beta-hydroxycortisol, an indicator of enzyme induction by rifampicin and antiepileptic drugs. Eur J Clin Pharmacol. 1979 Aug;16(1):63–71. doi: 10.1007/BF00644969. [DOI] [PubMed] [Google Scholar]
  24. Rose R. M., Kreuz L. E., Holaday J. W., Sulak K. J., Johnson C. E. Diurnal variation of plasma testosterone and cortisol. J Endocrinol. 1972 Jul;54(1):177–178. doi: 10.1677/joe.0.0540177. [DOI] [PubMed] [Google Scholar]
  25. Scharer L., Smith J. P. Serum transaminase elevations and other hepatic abnormalities in patients receiving isoniazid. Ann Intern Med. 1969 Dec;71(6):1113–1120. doi: 10.7326/0003-4819-71-6-1113. [DOI] [PubMed] [Google Scholar]
  26. Serlin M. J., Sibeon R. G., Mossman S., Breckenridge A. M., Williams J. R., Atwood J. L., Willoughby J. M. Cimetidine: interaction with oral anticoagulants in man. Lancet. 1979 Aug 18;2(8138):317–319. doi: 10.1016/s0140-6736(79)90340-4. [DOI] [PubMed] [Google Scholar]
  27. Smith S. E., Rawlins M. D. Prediction of drug oxidation rates in man: lack of correlation with serum gamma-glutamyl transpeptidase and urinary excretion of D-glucaric acid and 6 beta-hydroxycortisol. Eur J Clin Pharmacol. 1974;7(1):71–75. doi: 10.1007/BF00614394. [DOI] [PubMed] [Google Scholar]
  28. Thrasher K., Werk E. E., Jr, Choi Y., Sholiton L. J., Meyer W., Olinger C. The measurement, excretion, and source of urinary 6-hydroxycortisol in humans. Steroids. 1969 Nov;14(5):455–468. doi: 10.1016/s0039-128x(69)80040-1. [DOI] [PubMed] [Google Scholar]
  29. Vesell E. S. The antipyrine test in clinical pharmacology: conceptions and misconceptions. Clin Pharmacol Ther. 1979 Sep;26(3):275–286. doi: 10.1002/cpt1979263275. [DOI] [PubMed] [Google Scholar]
  30. Voccia E., Saenger P., Peterson R. E., Rauh W., Gottesdiener K., Levine L. S., New M. I. 6 beta-Hydroxycortisol excretion in hypercortisolemic states. J Clin Endocrinol Metab. 1979 Mar;48(3):467–471. doi: 10.1210/jcem-48-3-467. [DOI] [PubMed] [Google Scholar]
  31. WERK E. E., Jr, MACGEE J., SHOLITON L. J. EFFECT OF DIPHENYLHYDANTOIN ON CORTISOL METABOLISM IN MAN. J Clin Invest. 1964 Sep;43:1824–1835. doi: 10.1172/JCI105056. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Yamaji T., Motohashi K., Murakawa S., Ibayashi H. Urinary excretion of 6 beta-hydroxycortisol in states of altered thyroid function. J Clin Endocrinol Metab. 1969 Jun;29(6):801–806. doi: 10.1210/jcem-29-6-801. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES