Abstract
1 In six patients with chronic bronchitis, serial changes in both ventilatory function and plasma theophylline concentrations were measured simultaneously for 8 h following 500 mg aminophylline intravenously. 2 Using empirical mathematical models which can integrate this data, parameters were estimated which can express response as a linear function of steady state plasma theophylline levels. 3 Taking Forced Vital Capacity (FVC) as the target response, the mean (+/- s.d.) increase in FVC was 0.06 +/- 0.02 l/micrograms ml-1, starting with pretreatment values in the range 1-21. 4 This analytical approach could be used to determine whether or not a patient with chronic bronchitis could obtain a satisfactory response to theophylline at plasma levels normally encountered in clinical practice.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barclay J., Whiting B., Meredith P. A., Addis G. J. Theophylline-salbutamol interaction: bronchodilator response to salbutamol at maximally effective plasma theophylline concentrations. Br J Clin Pharmacol. 1981 Feb;11(2):203–208. doi: 10.1111/j.1365-2125.1981.tb01125.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kelman A. W., Whiting B. Modeling of drug response in individual subjects. J Pharmacokinet Biopharm. 1980 Apr;8(2):115–130. doi: 10.1007/BF01065188. [DOI] [PubMed] [Google Scholar]
- Sheiner L. B., Stanski D. R., Vozeh S., Miller R. D., Ham J. Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine. Clin Pharmacol Ther. 1979 Mar;25(3):358–371. doi: 10.1002/cpt1979253358. [DOI] [PubMed] [Google Scholar]
- Whiting B., Holford N. H., Sheiner L. B. Quantitative analysis of the disopyramide concentration-effect relationship. Br J Clin Pharmacol. 1980 Jan;9(1):67–75. doi: 10.1111/j.1365-2125.1980.tb04799.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Whiting B., Kelman A. W. The modelling of drug response. Clin Sci (Lond) 1980 Nov;59(5):311–315. doi: 10.1042/cs0590311. [DOI] [PubMed] [Google Scholar]
- Yamaoka K., Nakagawa T., Uno T. Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations. J Pharmacokinet Biopharm. 1978 Apr;6(2):165–175. doi: 10.1007/BF01117450. [DOI] [PubMed] [Google Scholar]