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British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1981 Oct;12(4):503–506. doi: 10.1111/j.1365-2125.1981.tb01257.x

Long-term cyclophosphamide treatment in rheumatoid patients: effects on serum sulphydryl levels, technetium index, ESR and clinical response.

M G Grimaldi
PMCID: PMC1401906  PMID: 7295485

Abstract

1 After 12 months cyclophosphamide administration the serum sulphydryl concentrations increased in all of twelve rheumatoid patients treated, and returned towards the normal range in eleven. 2 A decrease was observed in the technetium index, the erythrocyte sedimentation rate, and joint count. 3 Long-term cyclophosphamide-induced serum SH increase may represent a specific change in the process of the rheumatoid disease activity, possibly involving the pathogenic B cells.

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Selected References

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