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. 1981 Dec;12(6):849–853. doi: 10.1111/j.1365-2125.1981.tb01319.x

The effect of chronic propranolol treatment on overnight plasma levels of anterior pituitary and related hormones.

A M Dart, M J Lewis, G V Groom, E M Meek, A H Henderson
PMCID: PMC1401931  PMID: 7340886

Abstract

1 Treatment of eight healthy males with propranolol (80 mg twice daily) for 6 weeks resulted in a significant reduction in overnight plasma levels of prolactin and LH. 2 Plasma testosterone levels were elevated whilst GH and cortisol were unchanged by such treatment. 3 Measurement of overnight hormone levels 48 h after discontinuing treatment showed no evidence of a 'rebound' phenomenon. 4 Cortisol, GH, prolactin, and testosterone plasma levels all showed time dependent changes: propranolol treatment significantly altered the time course of cortisol but not of the other hormones. 5 The effects of chronic propranolol treatment are discussed in terms of a probable direct central action of the drug. In addition the lowered plasma prolactin levels may directly contribute to the hypotensive action of propranolol.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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