Abstract
1 In five volunteers taking daily subtherapeutic doses of warfarin the addition of ranitidine 200 mg twice daily for 14 days did not affect prothrombin time or plasma warfarin concentration. 2 Ranitidine had no effect on the single dose pharmacodynamics and pharmacokinetics of warfarin in the rat. 3 Ranitidine had no effect on pentobarbitone sleeping time in the rat whereas cimetidine significantly prolonged the sleeping time. 4 The interaction between cimetidine and oral anticoagulants is unrelated to histamine H2-receptor antagonism.
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Selected References
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- Henry D. A., Macdonald I. A., Kitchingman G., Bell G. D., Langman M. J. Cimetidine and ranitidine: comparison of effects on hepatic drug metabolism. Br Med J. 1980 Sep 20;281(6243):775–777. doi: 10.1136/bmj.281.6243.775. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kaiser D. G., Martin R. S. GLC determination of warfarin in human plasma. J Pharm Sci. 1974 Oct;63(10):1579–1581. doi: 10.1002/jps.2600631018. [DOI] [PubMed] [Google Scholar]
- Klotz U., Reimann I. Delayed clearance of diazepam due to cimetidine. N Engl J Med. 1980 May 1;302(18):1012–1014. doi: 10.1056/NEJM198005013021807. [DOI] [PubMed] [Google Scholar]
- Park B. K., Leck J. B., Wilson A. C., Serlin M. J., Breckenridge A. M. A study of the effect of anticoagulants on [3H]vitamin K1 metabolism and prothrombin complex activity in the rabbit. Biochem Pharmacol. 1979 Apr 15;28(8):1323–1329. doi: 10.1016/0006-2952(79)90433-7. [DOI] [PubMed] [Google Scholar]
- Peden N. R., Saunders J. H., Wormsley K. G. Inhibition of pentagastrin-stimulated and nocturnal gastric secretion by ranitidine. A new H2-receptor antagonist. Lancet. 1979 Mar 31;1(8118):690–692. doi: 10.1016/s0140-6736(79)91146-2. [DOI] [PubMed] [Google Scholar]
- Puurunen J., Sotaniemi E., Pelkonen O. Effect of cimetidine on microsomal drug metabolism in man. Eur J Clin Pharmacol. 1980 Aug;18(2):185–187. doi: 10.1007/BF00561588. [DOI] [PubMed] [Google Scholar]
- Serlin M. J., Challiner M., Park B. K., Turcan P. A., Breckenridge A. M. Cimetidine potentiates the anticoagulant effect of warfarin by inhibition of drug metabolism. Biochem Pharmacol. 1980 Jul 1;29(13):1971–1972. doi: 10.1016/0006-2952(80)90114-8. [DOI] [PubMed] [Google Scholar]
- Serlin M. J., Sibeon R. G., Mossman S., Breckenridge A. M., Williams J. R., Atwood J. L., Willoughby J. M. Cimetidine: interaction with oral anticoagulants in man. Lancet. 1979 Aug 18;2(8138):317–319. doi: 10.1016/s0140-6736(79)90340-4. [DOI] [PubMed] [Google Scholar]
- Yacobi A., Wingard L. B., Jr, Levy G. Comparative pharmacokinetics of coumarin anticoagulants. X. Relationship between distribution, elimination, and anticoagulant action of warfarin. J Pharm Sci. 1974 Jun;63(6):868–872. doi: 10.1002/jps.2600630613. [DOI] [PubMed] [Google Scholar]