Skip to main content
NCBI home page
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1981 Nov;12(5):731–735. doi: 10.1111/j.1365-2125.1981.tb01297.x

Effect of propranolol on the airway response to prostaglandin E2 in normal man.

R V Seth, V S Clarke, R A Lewis, A E Tattersfield
PMCID: PMC1401971  PMID: 7332739

Abstract

1 The airway response to inhaled prostaglandin E2 (PGE2) and the effect of oral propranolol on this response was studied in eight normal subjects in a double-blind randomised trial. The airway response was measured as specific airway conductance (sGaw). 2 Inhalation of PGE2 caused retrosternal soreness, coughing and an awareness of mucus production. Despite this, PGE2 caused bronchodilatation and reproducible dose-response curves were obtained, with a maximum increase in sGaw of 53%. 3 Inhalation of the diluent of PGE2, an ethanol/saline mixture, did not cause irritation nor did it alter sGaw. 4 Prior administration of propranolol 80 mg did not alter baseline sGAW, nor the response to PGE2, indicating that the action of PGE2 in vivo is unaffected by bronchial beta-adrenoceptor blockade. 5 This technique should be of value in studying bronchodilator prostaglandins and their interaction with other drugs.

Full text

PDF
731

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bergren D. R., Vidruk E. H., Sampson S. R. Effects of prostaglandins E1 and E2 on activity in laryngeal and pharyngeal afferent fibers. Prostaglandins. 1979 Apr;17(4):649–655. doi: 10.1016/0090-6980(79)90016-9. [DOI] [PubMed] [Google Scholar]
  2. Brody M. J., Kadowitz P. J. Prostaglandins as modulators of the autonomic nervous system. Fed Proc. 1974 Jan;33(1):48–60. [PubMed] [Google Scholar]
  3. Burges R. A., Blackburn K. J. Adenyl cyclase and the differentiation of -adrenoreceptors. Nat New Biol. 1972 Feb 23;235(60):249–250. doi: 10.1038/newbio235249a0. [DOI] [PubMed] [Google Scholar]
  4. Butcher R. W., Baird C. E. Effects of prostaglandins on adenosine 3',5'-monophosphate levels in fat and other tissues. J Biol Chem. 1968 Apr 25;243(8):1713–1717. [PubMed] [Google Scholar]
  5. Hedqvist P. Basic mechanisms of prostaglandin action on autonomic neurotransmission. Annu Rev Pharmacol Toxicol. 1977;17:259–279. doi: 10.1146/annurev.pa.17.040177.001355. [DOI] [PubMed] [Google Scholar]
  6. Karim S. M., Sandler M., Williams E. D. Distribution of prostaglandins in human tissues. Br J Pharmacol Chemother. 1967;31:340–344. doi: 10.1111/j.1476-5381.1967.tb02003.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Large B. J., Leswell P. F., Maxwell D. R. Bronchodilator activity of an aerosol of prostaglandin E1 in experimental animals. Nature. 1969 Oct 4;224(5214):78–80. doi: 10.1038/224078a0. [DOI] [PubMed] [Google Scholar]
  8. MAIN I. H. THE INHIBITORY ACTIONS OF PROSTAGLANDINS ON RESPIRATORY SMOOTH MUSCLE. Br J Pharmacol Chemother. 1964 Jun;22:511–519. doi: 10.1111/j.1476-5381.1964.tb01705.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mathé A. A., Hedqvist P. Effect of prostaglandins F2 alpha and E2 on airway conductance in healthy subjects and asthmatic patients. Am Rev Respir Dis. 1975 Mar;111(3):313–320. doi: 10.1164/arrd.1975.111.3.313. [DOI] [PubMed] [Google Scholar]
  10. Moore W. V., Wolff J. Binding of prostaglandin E1 to beef thyroid membranes. J Biol Chem. 1973 Aug 25;248(16):5705–5711. [PubMed] [Google Scholar]
  11. Nakanishi H., Yoshida H., Suzuki T. Inhibitory effects of prostaglandin E1 and E2 on cholinergic transmission in isolated canine tracheal muscle. Jpn J Pharmacol. 1976 Dec;26(6):669–674. doi: 10.1254/jjp.26.669. [DOI] [PubMed] [Google Scholar]
  12. Rao C. V. Characterization of prostaglandin receptors in the bovine corpus luteum cell membranes. J Biol Chem. 1974 Nov 25;249(22):7203–7209. [PubMed] [Google Scholar]
  13. Richardson P. S., Sterling G. M. Effects of beta-adrenergic receptor blockade on airway conductance and lung volume in normal and asthmatic subjects. Br Med J. 1969 Jul 19;3(5663):143–145. doi: 10.1136/bmj.3.5663.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Rosenthale M. E., Dervinis A., Begany A. J., Lapidus M., Gluckman M. I. Bronchodilator activity of prostaglandin E2 when administered by aerosol to 3 species. Experientia. 1970 Oct 15;26(10):1119–1121. doi: 10.1007/BF02112710. [DOI] [PubMed] [Google Scholar]
  15. Rosenthale M. E., Dervinis A., Strike D. Actions of prostaglandins on the respiratory tract of animals. Adv Prostaglandin Thromboxane Res. 1976;1:477–493. [PubMed] [Google Scholar]
  16. Sheard P. The effects of prostaglandin E1 on isolated bronchial muscle from man. J Pharm Pharmacol. 1968 Mar;20(3):232–233. doi: 10.1111/j.2042-7158.1968.tb09728.x. [DOI] [PubMed] [Google Scholar]
  17. Smith A. P., Cuthbert M. F., Dunlop L. S. Effects of inhaled prostaglandins E1, E2, and F2alpha on the airway resistance of healthy and asthmatic man. Clin Sci Mol Med. 1975 May;48(5):421–430. doi: 10.1042/cs0480421. [DOI] [PubMed] [Google Scholar]
  18. Sweatman W. J., Collier H. O. Effects of prostaglandins on human bronchial muscle. Nature. 1968 Jan 6;217(5123):69–69. doi: 10.1038/217069a0. [DOI] [PubMed] [Google Scholar]
  19. Tattersfield A. E., Leaver D. G., Pride N. B. Effects of beta-adrenergic blockade and stimulation on normal human airways. J Appl Physiol. 1973 Nov;35(5):613–619. doi: 10.1152/jappl.1973.35.5.613. [DOI] [PubMed] [Google Scholar]
  20. Wasserman M. A., Griffin R. L., Marsalisi F. B. Inhibition of bronchoconstriction by aerosols of prostaglandins E1 and E2. J Pharmacol Exp Ther. 1980 Jul;214(1):68–73. [PubMed] [Google Scholar]
  21. Weinryb I., Michel I. M., Hess S. M. Adenylate cyclase from guinea pig lung: further characterization and inhibitory effects of substrate analogs and cyclic nucleotides. Arch Biochem Biophys. 1973 Jan;154(1):240–249. doi: 10.1016/0003-9861(73)90054-4. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES