Abstract
1 A small dose of prazosin was added to the treatment regime of sixteen hypertensive patients poorly controlled on a combination of bendrofluazide, hydralazine and propranolol. 2 There was a significant improvement in blood pressure control in all patients at 1 month (P less than 0.01) and this was maintained at 9 months (P less than 0.02). Tolerance to prazosin was not a problem. 3 The addition of prazosin to conventional triple drug therapy produces a further useful fall in blood pressure.
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Selected References
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- Atkinson A. B., Robertson J. I. Captopril in the treatment of clinical hypertension and cardiac failure. Lancet. 1979 Oct 20;2(8147):836–839. doi: 10.1016/s0140-6736(79)92186-x. [DOI] [PubMed] [Google Scholar]
- Awan N. A., Miller R. R., Maxwell K., Mason D. T. Effects of prazosin on forearm resistance and capacitance vessels. Clin Pharmacol Ther. 1977 Jul;22(1):79–84. doi: 10.1002/cpt197722179. [DOI] [PubMed] [Google Scholar]
- Bing R. F., Russell G. I., Thurston H., Swales J. D. Hydrallazine in hypertension: is there a safe dose? Br Med J. 1980 Aug 2;281(6236):353–354. doi: 10.1136/bmj.281.6236.353. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Graham R. M., Thornell I. R., Gain J. M., Bagnoli C., Oates H. F., Stokes G. S. Prazosin: the first-dose phenomenon. Br Med J. 1976 Nov 27;2(6047):1293–1294. doi: 10.1136/bmj.2.6047.1293. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hua A. S., Macdonald I. M., Myers J. B., Fang P., Kincaid-Smith P. Studies with prazosin--a new effective hypotensive agent. II. Two double-blind cross-over studies comparing the effects of prazosin and hydrallazine. Med J Aust. 1977 Jul 2;2(1):5–9. [PubMed] [Google Scholar]
- Marshall A. J., Barritt D. W., Pocock J., Heaton S. T. Evaluation of beta blockade bendrofluazide, and prazosin in severe hypertension. Lancet. 1977 Feb 5;1(8006):271–274. doi: 10.1016/s0140-6736(77)91822-0. [DOI] [PubMed] [Google Scholar]
- Packer M., Meller J., Gorlin R., Herman M. V. Hemodynamic and clinical tachyphylaxis to prazosin-mediated afterload reduction in severe chronic congestive heart failure. Circulation. 1979 Mar;59(3):531–539. doi: 10.1161/01.cir.59.3.531. [DOI] [PubMed] [Google Scholar]
- Pettinger W. A. Minoxidil and the treatment of severe hypertension. N Engl J Med. 1980 Oct 16;303(16):922–926. doi: 10.1056/NEJM198010163031607. [DOI] [PubMed] [Google Scholar]
- Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. A cooperative study. JAMA. 1977 Jan 17;237(3):255–261. [PubMed] [Google Scholar]
- Taguchi J., Freis E. D. Partial versus complete control of blood pressure in the prevention of hypertensive complications. Circ Res. 1975 Jun;36(6 Suppl 1):257–260. doi: 10.1161/01.res.36.6.257. [DOI] [PubMed] [Google Scholar]