Abstract
1 Prizidilol hydrochloride (SK&F 92657) is a new compound which causes both arteriolar dilatation and beta-adrenoceptor blockade. The effect of a single oral dose on the responses of heart rate and blood pressure to isoprenaline infusion has been studied in healthy volunteers. 2 Isoprenaline heart rate dose-response curves showed parallel shifts to the right after oral prizidilol, indicating antagonism by this compound at beta-adrenoceptors in the heart. 3 Isoprenaline dose-response curves for decreases in diastolic blood pressure also showed shifts to the right after oral prizidilol, providing evidence of beta-adrenoceptor antagonism by this drug in peripheral resistance vessels. 4 The peak effect of a 40 mg dose of propranolol was greater than that of a 200 mg dose of prizidilol but both drugs caused persistent beta-adrenoceptor blockade for at least 7 h after ingestion.
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Selected References
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- Collier J. G., Pitcher D. W. Investigation of a combined arteriolar dilator and beta-adrenoceptor antagonist (SK & F 92657) in the peripheral vessels of man. Br J Clin Pharmacol. 1980 Dec;10(6):567–571. doi: 10.1111/j.1365-2125.1980.tb00512.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McDevitt D. G. The assessment of beta-adrenoceptor blocking drugs in man. Br J Clin Pharmacol. 1977 Aug;4(4):413–425. doi: 10.1111/j.1365-2125.1977.tb00756.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Steiner J. A., Clancy A., Manghani K. K., James I. M. Comparison of prizidilol hydrochloride (SK & F 92657), a new antihypertensive agent with beta-adrenoceptor antagonist and vasodilator activity with propranolol and hydralazine in normal volunteers. Br J Clin Pharmacol. 1981 Oct;12(4):573–578. doi: 10.1111/j.1365-2125.1981.tb01267.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Taylor E. M., Roe A. M., Slater R. A. SK&F 92657, a novel antihypertensive acting by precapillary vasodilatation and beta-adrenoreceptor blockade. Clin Sci (Lond) 1979 Dec;57 (Suppl 5):433s–436s. doi: 10.1042/cs057433s. [DOI] [PubMed] [Google Scholar]