Abstract
1 Clinically normal human abdominal skin in 11 subjects, was irradiated with three times the minimal-erythema dose of ultraviolet B (u.v. B) irradiation. 2 Erythema was assessed visually, and exudate was recovered by a suction bulla technique from normal skin, and from skin at 6, 24 and 48 h after irradiation. 3 Erythema was moderate at 6 h, but increased to a maximum at 24 h, which was maintained at 48 h. 4 6-oxo-PGF1 alpha was markedly raised at 6 h, moderately raised at 24 h, but had returned to control levels at 48 h, when the erythema was still maximal. 5 Prostaglandin I2, the precursor of 6-oxo-PGF1 alpha and 6-oxo-PGF1 alpha may, therefore, play a part in the early inflammatory process after u.v. B irradiation, but is unlikely to be responsible for the erythema still present at 48 h.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Black A. K., Fincham N., Greaves M. W., Hensby C. N. Time course changes in levels of arachidonic acid and prostaglandins D2, E2, F2 alpha in human skin following ultraviolet B irradiation. Br J Clin Pharmacol. 1980 Nov;10(5):453–457. doi: 10.1111/j.1365-2125.1980.tb01788.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Black A. K., Greaves M. W., Hensby C. N., Plummer N. A., Eady R. A. A new method for recovery of exudates from normal and inflamed human skin. Clin Exp Dermatol. 1977 Sep;2(3):209–216. doi: 10.1111/j.1365-2230.1977.tb02560.x. [DOI] [PubMed] [Google Scholar]
- Black A. K., Greaves M. W., Hensby C. N., Plummer N. A., Warin A. P. The effects of indomethacin on arachidonic acid and prostaglandins e2 and f2alpha levels in human skin 24 h after u.v.B and u.v.C irradiation. Br J Clin Pharmacol. 1978 Sep;6(3):261–266. doi: 10.1111/j.1365-2125.1978.tb04595.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Blackwell G. J., Flower R. J., Russell-Smith N., Salmon J. A., Thorogood P. B., Vane J. R. Prostacyclin is produced in whole blood [proceedings]. Br J Pharmacol. 1978 Nov;64(3):436P–436P. [PMC free article] [PubMed] [Google Scholar]
- Brodie M. J., Hensby C. N., Parke A., Gordon D. Is prostacyclin in the major pro-inflammatory prostanoid in joint fluid? Life Sci. 1980 Aug 18;27(7):603–608. doi: 10.1016/0024-3205(80)90310-0. [DOI] [PubMed] [Google Scholar]
- Dusting G. J., Moncada S., Mullane K. M., Vane J. R. Implications of prostacyclin generation for modulation of vascular tone. Clin Sci Mol Med Suppl. 1978 Dec;4:195s–198s. doi: 10.1042/cs055195s. [DOI] [PubMed] [Google Scholar]
- Dusting G. J., Moncada S., Vane J. R. Prostacyclin (PGX) is the endogenous metabolite responsible for relaxation of coronary arteries induced by arachindonic acid. Prostaglandins. 1977 Jan;13(1):3–15. doi: 10.1016/0090-6980(77)90037-5. [DOI] [PubMed] [Google Scholar]
- Eaglstein W. H., Sakai M., Mizuno N. Ultraviolet radiation-induced inflammation and leukocytes. J Invest Dermatol. 1979 Feb;72(2):59–63. doi: 10.1111/1523-1747.ep12530248. [DOI] [PubMed] [Google Scholar]
- Hensby C. N., Fitzgerald G. A., Friedman L. A., Lewis P. J., Dollery C. T. Measurement of 6-oxo-PGF1 alpha in human plasma using gas chromatography-mass spectrometry. Prostaglandins. 1979 Nov;18(5):731–736. doi: 10.1016/0090-6980(79)90093-5. [DOI] [PubMed] [Google Scholar]
- Humes J. L., Bonney R. J., Pelus L., Dahlgren M. E., Sadowski S. J., Kuehl F. A., Jr, Davies P. Macrophages synthesis and release prostaglandins in response to inflammatory stimuli. Nature. 1977 Sep 8;269(5624):149–151. doi: 10.1038/269149a0. [DOI] [PubMed] [Google Scholar]
- Weksler B. B., Marcus A. J., Jaffe E. A. Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells. Proc Natl Acad Sci U S A. 1977 Sep;74(9):3922–3926. doi: 10.1073/pnas.74.9.3922. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Whittaker N., Bunting S., Salmon J., Moncada S., Vane J. R., Johnson R. A., Morton D. R., Kinner J. H., Gorman R. R., McGuire J. C. The chemical structure of prostaglandin X (prostacyclin). Prostaglandins. 1976 Dec;12(6):915–928. doi: 10.1016/0090-6980(76)90126-x. [DOI] [PubMed] [Google Scholar]