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. 1982;13(Suppl 2):175S–180S. doi: 10.1111/j.1365-2125.1982.tb01907.x

Intrinsic sympathomimetic activity and coronary blood flow.

A Berdeaux, J F Giudicelli
PMCID: PMC1402155  PMID: 6125167

Abstract

1 The effects of four beta-adrenoceptor blocking agents, propranolol, pindolol, practolol and atenolol, used in doses inducing the same degree of beta 1-adrenoceptor blockade, have been investigated on regional myocardial blood flow (microspheres) and coronary vascular resistance in the normal and ischaemic myocardium of the anaesthetized dog. 2 In the ischaemic and non-ischaemic myocardial areas, transmural blood flow was significantly reduced by propranolol and atenolol which are devoid of intrinsic sympathomimetic activity (ISA) while it remained unaffected by beta-adrenoceptor blocking drugs endowed with ISA, whether cardioselective (practolol) or not (pindolol). In non-ischaemic areas, only propranolol and atenolol increased coronary vascular resistance. 3 Regarding coronary blood flow distribution between the epicardium and endocardium, only propranolol and pindolol induced a favourable redistribution towards the endocardium increasing the endo/epi flow ratio, while practolol and atenolol were ineffective. 4 These results suggest that ISA is of major importance in maintaining coronary flow especially in the ischaemic myocardium but that it is not involved in the mechanisms underlying coronary blood flow redistribution between the different myocardial layers.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ablad B., Brogård M., Ek L. Pharmacological properties of H 56-28--a beta-adrenergic receptor antagonist. Acta Pharmacol Toxicol (Copenh) 1967;25:9–40. [PubMed] [Google Scholar]
  2. Adam K. R., Boyles S. M. Haemodynamic and coronary vascular responses after beta-adrenoceptor blockade in the anaesthetised dog: a comparison of tolamolol with practolol and propranolol. Eur J Pharmacol. 1974 Apr;26(1):96–107. doi: 10.1016/0014-2999(74)90079-x. [DOI] [PubMed] [Google Scholar]
  3. BERNE R. M. REGULATION OF CORONARY BLOOD FLOW. Physiol Rev. 1964 Jan;44:1–29. doi: 10.1152/physrev.1964.44.1.1. [DOI] [PubMed] [Google Scholar]
  4. Barrett A. M., Carter J., Fitzgerald J. D., Hull R., Le Count D. A new type of cardioselective adrenoceptive blocking drug. Br J Pharmacol. 1973 Jun;48(2):340P–340P. [PMC free article] [PubMed] [Google Scholar]
  5. Becker L. C., Ferreira R., Thomas M. Effect of propranolol and isoprenaline on regional left ventricular blood flow in experimental myocardial ischaemia. Cardiovasc Res. 1975 Mar;9(2):178–186. doi: 10.1093/cvr/9.2.178. [DOI] [PubMed] [Google Scholar]
  6. Becker L. C., Ferreira R., Thomas M. Mapping of left ventricular blood flow with radioactive microspheres in experimental coronary artery occlusion. Cardiovasc Res. 1973 May;7(3):391–400. doi: 10.1093/cvr/7.3.391. [DOI] [PubMed] [Google Scholar]
  7. Becker L. C., Fortuin N. J., Pitt B. Effect of ischemia and antianginal drugs on the distribution of radioactive microspheres in the canine left ventricle. Circ Res. 1971 Feb;28(2):263–269. doi: 10.1161/01.res.28.2.263. [DOI] [PubMed] [Google Scholar]
  8. Berdaux A., Bossier J. R., Giudicelli J. F. Effects of atenolol on regional myocardial blood flow and ST segment elevation in the canine myocardium. Br J Pharmacol. 1977 Jul;60(3):433–439. doi: 10.1111/j.1476-5381.1977.tb07519.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Berdeaux A., Peres da Costa C., Garnier M., Boissier J. R., Giudicelli J. F. Beta adrenergic blockade, regional left ventricular blood flow and ST-segment elevation in canine experimental myocardial ischemia. J Pharmacol Exp Ther. 1978 Jun;205(3):646–656. [PubMed] [Google Scholar]
  10. Buck J. D., Gross G. J., Warltier D. C., Jolly S. R., Hardman H. F. Comparative effects of cardioselective versus noncardioselective beta blockade on subendocardial blood flow and contractile function in ischemic myocardium. Am J Cardiol. 1979 Oct;44(4):657–663. doi: 10.1016/0002-9149(79)90284-4. [DOI] [PubMed] [Google Scholar]
  11. Domenech R. J., Hoffman J. I., Noble M. I., Saunders K. B., Henson J. R., Subijanto S. Total and regional coronary blood flow measured by radioactive microspheres in conscious and anesthetized dogs. Circ Res. 1969 Nov;25(5):581–596. doi: 10.1161/01.res.25.5.581. [DOI] [PubMed] [Google Scholar]
  12. Dunlop D., Shanks R. G. Selective blockade of adrenoceptive beta receptors in the heart. Br J Pharmacol Chemother. 1968 Jan;32(1):201–218. doi: 10.1111/j.1476-5381.1968.tb00444.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Giudicelli J. F., Schmitt H., Boissier J. R. Studies on dl-4-(2-hydroxy-3-isopropylaminopropoxy)-indole A/Giudicelli JF, Schmitt H, Boissier JR: Studies on dl-4-(2-hydroxy-3-isopropylaminopropoxy)-indole (LB 46), a new potent beta adrenergic blocking drug. J Pharmacol Exp Ther. 1969 Jul;168(1):116–126. [PubMed] [Google Scholar]
  14. Gross G. J., Feigl E. O. Analysis of coronary vascular beta receptors in situ. Am J Physiol. 1975 Jun;228(6):1909–1913. doi: 10.1152/ajplegacy.1975.228.6.1909. [DOI] [PubMed] [Google Scholar]
  15. Gross G. J., Winbury M. M. Beta adrenergic blockade on intramyocardial distribution of coronary blood flow. J Pharmacol Exp Ther. 1973 Dec;187(3):451–464. [PubMed] [Google Scholar]
  16. Libby P., Maroko P. R., Covell J. W., Malloch C. I., Ross J., Jr, Braunwald E. Effect of practolol on the extent of myocardial ischaemic injury after experimental coronary occlusion and its effects of ventricular function in the normal and ischaemic heart. Cardiovasc Res. 1973 Mar;7(2):167–173. doi: 10.1093/cvr/7.2.167. [DOI] [PubMed] [Google Scholar]
  17. Marshall R. J., Parratt J. R. Comparative effects of propranolol and practolol in the early stages of experimental canine myocardial infarction. Br J Pharmacol. 1976 Jun;57(2):295–303. doi: 10.1111/j.1476-5381.1976.tb07479.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Parratt J. R., Grayson J. Myocardial vascular reactivity after beta-adrenergic blockade. Lancet. 1966 Feb 12;1(7433):338–340. doi: 10.1016/s0140-6736(66)91321-3. [DOI] [PubMed] [Google Scholar]
  19. Parratt J. R., Marshall R. J., Ledingham I. M. Interventions for improving blood flow, oxygen availability and the balance between oxygen supply and demand in the acutely ischaemic myocardium. J Physiol (Paris) 1980;76(7):791–803. [PubMed] [Google Scholar]
  20. Parratt J. R., Wadsworth R. M. The effect of "selective" beta-adrenoceptor blocking drugs on the myocardial circulation. Br J Pharmacol. 1970 Jun;39(2):296–308. doi: 10.1111/j.1476-5381.1970.tb12893.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Reimer K. A., Rasmussen M. M., Jennings R. B. Reduction by propranolol of myocardial necrosis following temporary coronary artery occlusion in dogs. Circ Res. 1973 Sep;33(3):353–363. doi: 10.1161/01.res.33.3.353. [DOI] [PubMed] [Google Scholar]
  22. Sonnenblick E. H., Ross J., Jr, Braunwald E. Oxygen consumption of the heart. Newer concepts of its multifactoral determination. Am J Cardiol. 1968 Sep;22(3):328–336. doi: 10.1016/0002-9149(68)90117-3. [DOI] [PubMed] [Google Scholar]
  23. Warltier D. C., Gross G. J., Hardman H. F. Effect of propranolol on regional myocardial blood flow and oxygen consumption. J Pharmacol Exp Ther. 1976 Aug;198(2):435–443. [PubMed] [Google Scholar]
  24. ZUBERBUHLER R. C., BOHR D. F. RESPONSES OF CORONARY SMOOTH MUSCLE TO CATECHOLAMINES. Circ Res. 1965 May;16:431–440. doi: 10.1161/01.res.16.5.431. [DOI] [PubMed] [Google Scholar]

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