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. 1974 Aug;1(4):313–317. doi: 10.1111/j.1365-2125.1974.tb00259.x

Effect of angiotensin-converting enzyme inhibitor on response of plasma renin activity and aldosterone to tilting in man

J G Collier, J S Jenkins, J Keddie, M U A Khan, B F Robinson
PMCID: PMC1402432  PMID: 22454885

Abstract

1 The effect of an angiotensin-converting enzyme inhibitor (SQ 20,881; 0.5 mg/kg) on the response to tilting of plasma renin activity (PRA), plasma aldosterone and cortisol was studied in five normal subjects.

2 PRA rose significantly in both the supine and upright positions following administration of SQ 20,881; no significant effect on aldosterone or cortisol was observed.

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Selected References

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  1. Balikian H. M., Brodie A. H., Dale S. L., Melby J. C., Tait J. F. Effect of posture on the metabolic clearance rate, plasma concentration and blood production rate of aldosterone in man. J Clin Endocrinol Metab. 1968 Nov;28(11):1630–1640. doi: 10.1210/jcem-28-11-1630. [DOI] [PubMed] [Google Scholar]
  2. Bing J. Rapid marked increase in plasma renin in rats treated with inhibitors of the renin system. Effects of 1-sar-8-ala-angiotensin II and of a synthetic converting enzyme inhibitor (nonapeptide, SQ 20.881) on normal and adrenalectomized rats. Acta Pathol Microbiol Scand A. 1973 May;81(3):376–378. [PubMed] [Google Scholar]
  3. Brunner H. R., Gavras H., Laragh J. H. Angiotensin-II blockade in man by sar1-ala8-angiotensin II for understanding and treatment of high blood-pressure. Lancet. 1973 Nov 10;2(7837):1045–1048. doi: 10.1016/s0140-6736(73)92657-3. [DOI] [PubMed] [Google Scholar]
  4. Brunner H. R., Laragh J. H., Baer L., Newton M. A., Goodwin F. T., Krakoff L. R., Bard R. H., Bühler F. R. Essential hypertension: renin and aldosterone, heart attack and stroke. N Engl J Med. 1972 Mar 2;286(9):441–449. doi: 10.1056/NEJM197203022860901. [DOI] [PubMed] [Google Scholar]
  5. Gordon R. D., Wolfe L. K., Island D. P., Liddle G. W. A diurnal rhythm in plasma renin activity in man. J Clin Invest. 1966 Oct;45(10):1587–1592. doi: 10.1172/JCI105464. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Haber E., Koerner T., Page L. B., Kliman B., Purnode A. Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects. J Clin Endocrinol Metab. 1969 Oct;29(10):1349–1355. doi: 10.1210/jcem-29-10-1349. [DOI] [PubMed] [Google Scholar]
  7. Ito T., Woo J., Haning R., Horton R. A radioimmunoassay for aldosterone in human peripheral plasma including a comparison of alternate techniques. J Clin Endocrinol Metab. 1972 Jan;34(1):106–112. doi: 10.1210/jcem-34-1-106. [DOI] [PubMed] [Google Scholar]
  8. Miller E. D., Jr, Samuels A. I., Haber E., Barger A. C. Inhibition of angiotensin conversion in experimental renovascular hypertension. Science. 1972 Sep 22;177(4054):1108–1109. doi: 10.1126/science.177.4054.1108. [DOI] [PubMed] [Google Scholar]
  9. Mitra S., Genuth S. M., Berman L. B., Vertes V. Aldosterone secretion in anephric patients. N Engl J Med. 1972 Jan 13;286(2):61–64. doi: 10.1056/NEJM197201132860204. [DOI] [PubMed] [Google Scholar]
  10. SPENCER PEET J., DALY J. R., SMITH V. A SIMPLE METHOD FOR IMPROVING THE SPECIFICITY OF THE FLUORIMETRIC DETERMINATION OF ADRENAL CORTICOSTEROIDS IN HUMAN PLASMA. J Endocrinol. 1965 Feb;31:235–244. doi: 10.1677/joe.0.0310235. [DOI] [PubMed] [Google Scholar]

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