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. 1975 Feb;2(1):57–63. doi: 10.1111/j.1365-2125.1975.tb00472.x

The effect of metoclopramide on the absorption of effervescent aspirin in migraine.

G N Volans
PMCID: PMC1402484  PMID: 791318

Abstract

1 The absorption of effervescent aspirin was studied in two groups of patients during attacks of migraine. The first group received effervescent aspirin alone whilst the second group received intramuscular metoclopramide before effervescent aspirin. 2 After effervescent aspirin alone there was significant impairment in the rate of aspirin absorption during migraine attacks compared with the rate of aspirin absorption in normal volunteers and in the same patients when headache-free. 3 When metoclopramide was given before effervescent aspirin the rate of aspirin absorption during migraine attacks was not significantly different from that obtained in normal volunteers given effervescent aspirin alone or from that obtained in the patients themselves when given both metoclopramide and effervescent aspirin when headache-free. 4 It is concluded that the impairment of absorption of effervescent aspirin during migraine attacks is related to impaired gastro-intestinal motility with delayed gastric emptying and that this impaired motility can be overcome by parenteral metoclopramide.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bertrand J. Comment concevoir actuellement le traitement des migraines digestives? Sem Ther. 1966 Mar;42(3):149–150. [PubMed] [Google Scholar]
  2. Bynum T. E., Jacobson E. D. Blood flow and gastrointestinal function. Gastroenterology. 1971 Feb;60(2):325–335. [PubMed] [Google Scholar]
  3. CUMMINGS A. J., MARTIN B. K. FACTORS INFLUENCING THE PLASMA SALICYLATE CONCENTRATION AND URINARY SALICYLATE EXCRETION AFTER ORAL DOSAGE WITH ASPIRIN. Biochem Pharmacol. 1964 May;13:767–776. doi: 10.1016/0006-2952(64)90013-9. [DOI] [PubMed] [Google Scholar]
  4. Connell A. M., George J. D. Effect of metoclopramide on gastric function in man. Gut. 1969 Aug;10(8):678–680. doi: 10.1136/gut.10.8.678. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cudworth A. G. Carcinoma of the pancreas and hyperosmolar coma. Postgrad Med J. 1973 Jan;49(567):56–58. doi: 10.1136/pgmj.49.567.56. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. GRIVAUX M., LAMOTTE-BARRILLON S. LES NAUS'EES, LA BARRE 'EPIGASTRIQUE, LE HOQUET ET LES MIGRAINES. LEUR TRAITEMENT PAR LE M'ETOCLOPRAMIDE. Sem Hop. 1964 Oct 14;40:2357–2361. [PubMed] [Google Scholar]
  7. Hall M. R. Drug therapy in the elderly. Br Med J. 1973 Sep 15;3(5880):582–584. doi: 10.1136/bmj.3.5880.582. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Howard F. A., Sharp D. S. The effect of intra-muscular metoclopramide on gastric emptying during labour. Postgrad Med J. 1973 Jul;49 (Suppl 4):suppl 4–4:57. [PubMed] [Google Scholar]
  9. Jacoby H. I., Brodie D. A. Gastrointestinal actions of metoclopramide. An experimental study. Gastroenterology. 1967 Apr;52(4):676–684. [PubMed] [Google Scholar]
  10. Kendall M. J. Intestinal motility and absorption. Br Med J. 1973 Apr 21;2(5859):179–179. doi: 10.1136/bmj.2.5859.179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Nimmo J., Heading R. C., Tothill P., Prescott L. F. Pharmacological modification of gastric emptying: effects of propantheline and metoclopromide on paracetamol absorption. Br Med J. 1973 Mar 10;1(5853):587–589. doi: 10.1136/bmj.1.5853.587. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. TRUITT E. B., Jr, MORGAN A. M. GASTROINTESTINAL FACTORS IN ASPIRIN ABSORPTION. A QUANTITATIVE STUDY. J Pharm Sci. 1964 Feb;53:129–134. doi: 10.1002/jps.2600530203. [DOI] [PubMed] [Google Scholar]
  13. Takaori S., Nakai Y., Matsuoka I., Sasa M., Fukuda N., Shimamoto K. The mechanism of antagonism between apomorphine and metoclopramide on unit discharges from nuclear structures in the brainstem of the cat. Int J Neuropharmacol. 1968 Mar;7(2):115–126. doi: 10.1016/0028-3908(68)90005-1. [DOI] [PubMed] [Google Scholar]
  14. Volans G. N. Absorption of effervescent aspirin during migraine. Br Med J. 1974 Nov 2;4(5939):265–268. doi: 10.1136/bmj.4.5939.265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Wilkinson M. Migraine--treatment of acute attack. Br Med J. 1971 Jun 26;2(5764):754–755. doi: 10.1136/bmj.2.5764.754. [DOI] [PMC free article] [PubMed] [Google Scholar]

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