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. 1975 Feb;2(1):69–72. doi: 10.1111/j.1365-2125.1975.tb00474.x

Changes in drug metabolism with increasing age: 1. warfarin binding and plasma proteins.

M J Hayes, M J Langman, A H Short
PMCID: PMC1402487  PMID: 1234489

Abstract

1 A decrease was found in the binding capacity of elderly people for warfarin. 2 The decrease in binding correlated with a fall in plasma albumin concentrations. 3 No changes in the association constant were observed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Haferkamp O., Schlettwein-Gsell D., Schwick H. G., Störiko K. Serum protein in an aging population with particular reference to evaluation of immune globulins and antibodies. Gerontologia. 1966;12(1):30–36. doi: 10.1159/000211530. [DOI] [PubMed] [Google Scholar]
  2. Hurwitz N. Predisposing factors in adverse reactions to drugs. Br Med J. 1969 Mar 1;1(5643):536–539. doi: 10.1136/bmj.1.5643.536. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  4. Ness A. T., Dickerson H. C., Pastewka J. V. The determination of human serum albumin by its specific binding of the anionic dye, 2-(4'-hydroxybenzeneazo)-benzoic acid. Clin Chim Acta. 1965 Nov;12(5):532–541. doi: 10.1016/0009-8981(65)90168-3. [DOI] [PubMed] [Google Scholar]
  5. O'Reilly R. A. Interaction of the anticoagulant drug warfarin and its metabolites with human plasma albumin. J Clin Invest. 1969 Jan;48(1):193–202. doi: 10.1172/JCI105968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. O'Reilly R. A. Studies on the coumarin anticoagulant drugs: interaction of human plasma albumin and warfarin sodium. J Clin Invest. 1967 May;46(5):829–837. doi: 10.1172/JCI105582. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. PARFENTJEV I. A., JOHNSON M. L. The plasma protein pattern and its significance in geriatrics and cancer diagnosis. Geriatrics. 1955 May;10(5):232–238. [PubMed] [Google Scholar]
  8. PEYMAN M. A. The significance of haemorrhage during the treatment of patients with the coumarin anticoagulants. Acta Med Scand Suppl. 1958;339:1–62. doi: 10.1111/j.0954-6820.1958.tb17330.x. [DOI] [PubMed] [Google Scholar]
  9. RAFSKY H. A., BRILL A. A., STERN K. G., COREY H. Electrophoretic studies on the serum of normal aged individuals. Am J Med Sci. 1952 Nov;224(5):522–528. doi: 10.1097/00000441-195211000-00007. [DOI] [PubMed] [Google Scholar]

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