Abstract
1 A controlled trial of charcoal haemoperfusion as an early treatment for paracetamol overdose showed no benefit.
2 The plasma clearances of paracetamol by the charcoal column were variable and disappointingly small (range 4-119 ml/minute). The cumulative amounts removed were also low, mean 1.4 g (range 0.2-5.2 g).
3 No clinical problems were encountered with the technique of haemoperfusion and in particular the drop in blood platelet counts was small (mean fall 16%).
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Selected References
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