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. 1975 Dec;2(6):503–508. doi: 10.1111/j.1365-2125.1975.tb00567.x

Intravenous infusion of salbutamol in the treatment of asthma.

S G Spiro, A J Johnson
PMCID: PMC1402645  PMID: 1234014

Abstract

The effects of i.v. infusion of increasing rates of salbutamol for up to 4 h were documented in ten convalescent asthmatic patients. 2 The major bronchodilator effect was seen at 4.16 mug/minute. A small further improvement occurred at infusion rates up to 25.0 mug/min but was not significantly better than that seen at the lower infusion rate. 3 Cardiovascular effects were minimal after 60 min at the lower rate and even at 25.0 mug/min mean heart rate rose by only 17.1 beats/minute. All patients tolerated the 4 h infusion well. 4 It is concluded that i.v. infusion of salbutamol may be a useful addition to the treatment of the patient with a severe attack of asthma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atkinson J. M., Rand M. J. Mutal suppression of cardiovascular effects of some beta-adrenoreceptor agonists in the cat. J Pharm Pharmacol. 1968 Dec;20(12):916–922. doi: 10.1111/j.2042-7158.1968.tb09674.x. [DOI] [PubMed] [Google Scholar]
  2. Choo-Kang Y. F., Parker S. S., Grant I. W. Response of asthmatics to isoprenaline and salbutamol aerosols administered by intermittent positive-pressure ventilation. Br Med J. 1970 Nov 21;4(5733):465–468. doi: 10.1136/bmj.4.5733.465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Conolly M. E., Davies D. S., Dollery C. T., George C. F. Resistance to -adrenoceptor stimulants (a possible explanation for the rise in ashtma deaths). Br J Pharmacol. 1971 Oct;43(2):389–402. [PMC free article] [PubMed] [Google Scholar]
  4. Gibson D. G., Coltart D. J. Haemodynamic effects of intravenous salbutamol in patients with mitral valve disease: comparison with isoprenaline and atropine. Postgrad Med J. 1971 Mar;47(Suppl):40–44. [PubMed] [Google Scholar]
  5. Kamburoff P. L., Rime F. J. Oral and inhaled salbutamol as a bronchodilator. Br J Dis Chest. 1970 Jan;64(1):46–54. doi: 10.1016/s0007-0971(70)80048-1. [DOI] [PubMed] [Google Scholar]
  6. Keighley J. F. Iatrogenic asthma associated with adrenergic aerosols. Ann Intern Med. 1966 Nov;65(5):985–995. doi: 10.7326/0003-4819-65-5-985. [DOI] [PubMed] [Google Scholar]
  7. Kingsley P. J., Littlejohns D. W., Prichard B. N. Isoprenaline-induced tachycardia in man. Br J Pharmacol. 1972 Nov;46(3):539P–540P. [PMC free article] [PubMed] [Google Scholar]
  8. Liggins G. C., Vaughan G. S. Intravenous infusion of salbutamol in the management of premature labour. J Obstet Gynaecol Br Commonw. 1973 Jan;80(1):29–32. doi: 10.1111/j.1471-0528.1973.tb02126.x. [DOI] [PubMed] [Google Scholar]
  9. Mitenko P. A., Ogilvie R. I. Rapidly achieved plasma concentration plateaus, with observations on theophylline kinetics. Clin Pharmacol Ther. 1972 May-Jun;13(3):329–335. doi: 10.1002/cpt1972133329. [DOI] [PubMed] [Google Scholar]
  10. Ng K. H., Sen D. K. Letter: Hypotension with intravenous salbutamol in premature labour. Br Med J. 1974 Jul 27;3(5925):257–257. doi: 10.1136/bmj.3.5925.257-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Paterson J. W., Evans R. J., Prime F. J. SElectivity of broncholidlator action of salbutamol in asthmatic patients. Br J Dis Chest. 1971 Jan;65(1):21–38. [PubMed] [Google Scholar]
  12. Svedmyr N., Thiringer G. The effects of salbutamol and isoprenaline on beta-receptors in patients with chronic obstructive lung disease. Postgrad Med J. 1971 Mar;47(Suppl):44–46. doi: 10.1136/pgmj.47.543.44. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Tattersfield A. E., McNicol M. W. Salbutamol and isoproterenol. A double-blind trial to compare bronchodilator and cardiovascular activity. N Engl J Med. 1969 Dec 11;281(24):1323–1326. doi: 10.1056/NEJM196912112812402. [DOI] [PubMed] [Google Scholar]
  14. Van Metre T. E., Jr Adverse effects of inhalation of excessive amounts of nebulized isoproterenol in status asthmaticus. J Allergy. 1969 Feb;43(2):101–113. doi: 10.1016/0021-8707(69)90130-0. [DOI] [PubMed] [Google Scholar]
  15. Walker S. R., Evans M. E., Richards A. J., Paterson J. W. The clinical pharmacology of oral and inhaled salbutamol. Clin Pharmacol Ther. 1972 Nov-Dec;13(6):861–867. doi: 10.1002/cpt1972136861. [DOI] [PubMed] [Google Scholar]
  16. Warrell D. A., Robertson D. G., Howes J. N., Conolly M. E., Paterson J. W., Beilin L. J., Dollery C. T. Comparison of cardiorespiratory effects of isoprenaline and salbutamol in patients with bronchial asthma. Br Med J. 1970 Jan 10;1(5688):65–70. [PMC free article] [PubMed] [Google Scholar]

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