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. 1990 Jun;80(6):675–678. doi: 10.2105/ajph.80.6.675

Nongenetic influences of obesity on other cardiovascular disease risk factors: an analysis of identical twins.

B Newman 1, J V Selby 1, C P Quesenberry Jr 1, M C King 1, G D Friedman 1, R R Fabsitz 1
PMCID: PMC1404714  PMID: 2343948

Abstract

The importance of genetic influences on obesity has been emphasized recently. We conducted matched co-twin analyses of 250 pairs of White, male, monozygotic twins from the National Heart, Lung, and Blood Institute (NHLBI) Twin Study. Entirely in the absence of genetic influences, obesity was significantly associated with systolic and diastolic blood pressures; one-hour, post-load glucose; total, LDL-, and HDL-cholesterol; and triglycerides among these 42-55 year old men. Similar results were obtained in longitudinal analyses of weight change during adulthood (from mean age of 20 to mean age of 48 years) and risk factor status at middle-age. These results indicate that behaviors and environmental exposures that occur later in life are responsible, at least in part, for the associations between adult obesity and cardiovascular disease risk, supporting the appropriateness of weight reduction efforts during adulthood.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ashley F. W., Jr, Kannel W. B. Relation of weight change to changes in atherogenic traits: the Framingham Study. J Chronic Dis. 1974 Mar;27(3):103–114. doi: 10.1016/0021-9681(74)90079-4. [DOI] [PubMed] [Google Scholar]
  2. Austin M. A., King M. C., Bawol R. D., Hulley S. B., Friedman G. D. Risk factors for coronary heart disease in adult female twins. Genetic heritability and shared environmental influences. Am J Epidemiol. 1987 Feb;125(2):308–318. doi: 10.1093/oxfordjournals.aje.a114531. [DOI] [PubMed] [Google Scholar]
  3. Borkan G. A., Sparrow D., Wisniewski C., Vokonas P. S. Body weight and coronary disease risk: patterns of risk factor change associated with long-term weight change. The Normative Aging Study. Am J Epidemiol. 1986 Sep;124(3):410–419. doi: 10.1093/oxfordjournals.aje.a114411. [DOI] [PubMed] [Google Scholar]
  4. Bouchard C., Pérusse L., Leblanc C., Tremblay A., Thériault G. Inheritance of the amount and distribution of human body fat. Int J Obes. 1988;12(3):205–215. [PubMed] [Google Scholar]
  5. Bouchard C., Tremblay A., Despres J. P., Poehlman E. T., Theriault G., Nadeau A., Lupien P., Moorjani S., Dussault J. Sensitivity to overfeeding: the Quebec experiment with identical twins. Prog Food Nutr Sci. 1988;12(1):45–72. [PubMed] [Google Scholar]
  6. Burton B. T., Foster W. R., Hirsch J., Van Itallie T. B. Health implications of obesity: an NIH Consensus Development Conference. Int J Obes. 1985;9(3):155–170. [PubMed] [Google Scholar]
  7. Fabsitz R., Feinleib M., Hubert H. Regression analysis of data with correlated errors: an example from the NHLBI twin study. J Chronic Dis. 1985;38(2):165–170. doi: 10.1016/0021-9681(85)90089-x. [DOI] [PubMed] [Google Scholar]
  8. Feinleib M., Christian J. C., Borhani N. O., Rosenman R., Garrison R. J., Wagner J., Kannel W. B., Hrubec Z., Schwartz J. T. The National Heart and Lung Institute twin study of cardiovascular disease risk factors: organization and methodology. Acta Genet Med Gemellol (Roma) 1976;25:125–128. doi: 10.1017/s0001566000013970. [DOI] [PubMed] [Google Scholar]
  9. Feinleib M., Garrison R. J., Fabsitz R., Christian J. C., Hrubec Z., Borhani N. O., Kannel W. B., Rosenman R., Schwartz J. T., Wagner J. O. The NHLBI twin study of cardiovascular disease risk factors: methodology and summary of results. Am J Epidemiol. 1977 Oct;106(4):284–285. doi: 10.1093/oxfordjournals.aje.a112464. [DOI] [PubMed] [Google Scholar]
  10. Gesell A. THE METHOD OF CO-TWIN CONTROL. Science. 1942 May 1;95(2470):446–448. doi: 10.1126/science.95.2470.446. [DOI] [PubMed] [Google Scholar]
  11. Gillum R. F., Taylor H. L., Brozek J., Anderson J., Blackburn H. Blood lipids in young men followed 32 years. J Chronic Dis. 1982;35(8):635–641. doi: 10.1016/0021-9681(82)90015-7. [DOI] [PubMed] [Google Scholar]
  12. Hubert H. B. The importance of obesity in the development of coronary risk factors and disease: the epidemiologic evidence. Annu Rev Public Health. 1986;7:493–502. doi: 10.1146/annurev.pu.07.050186.002425. [DOI] [PubMed] [Google Scholar]
  13. Jablon S., Neel J. V., Gershowitz H., Atkinson G. F. The NAS-NRC twin panel: methods of construction of the panel, zygosity diagnosis, and proposed use. Am J Hum Genet. 1967 Mar;19(2):133–161. [PMC free article] [PubMed] [Google Scholar]
  14. Khoury P., Morrison J. A., Mellies M. J., Glueck C. J. Weight change since age 18 years in 30- to 55-year-old whites and blacks. Associations with lipid values, lipoprotein levels, and blood pressure. JAMA. 1983 Dec 16;250(23):3179–3187. [PubMed] [Google Scholar]
  15. King M. C., Lee G. M., Spinner N. B., Thomson G., Wrensch M. R. Genetic epidemiology. Annu Rev Public Health. 1984;5:1–52. doi: 10.1146/annurev.pu.05.050184.000245. [DOI] [PubMed] [Google Scholar]
  16. Perkins K. A. Family history of coronary heart disease: is it an independent risk factor? Am J Epidemiol. 1986 Aug;124(2):182–194. doi: 10.1093/oxfordjournals.aje.a114377. [DOI] [PubMed] [Google Scholar]
  17. Price R. A., Cadoret R. J., Stunkard A. J., Troughton E. Genetic contributions to human fatness: an adoption study. Am J Psychiatry. 1987 Aug;144(8):1003–1008. doi: 10.1176/ajp.144.8.1003. [DOI] [PubMed] [Google Scholar]
  18. Price R. A., Stunkard A. J. Commingling analysis of obesity in twins. Hum Hered. 1989;39(3):121–135. doi: 10.1159/000153848. [DOI] [PubMed] [Google Scholar]
  19. Simopoulos A. P., Van Itallie T. B. Body weight, health, and longevity. Ann Intern Med. 1984 Feb;100(2):285–295. doi: 10.7326/0003-4819-100-2-285. [DOI] [PubMed] [Google Scholar]
  20. Stunkard A. J., Foch T. T., Hrubec Z. A twin study of human obesity. JAMA. 1986 Jul 4;256(1):51–54. [PubMed] [Google Scholar]
  21. Stunkard A. J., Sørensen T. I., Hanis C., Teasdale T. W., Chakraborty R., Schull W. J., Schulsinger F. An adoption study of human obesity. N Engl J Med. 1986 Jan 23;314(4):193–198. doi: 10.1056/NEJM198601233140401. [DOI] [PubMed] [Google Scholar]

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