Skip to main content
American Journal of Public Health logoLink to American Journal of Public Health
. 1991 Apr;81(4):491–494. doi: 10.2105/ajph.81.4.491

Capacity of US labs to provide TLI in support of early HIV-1 intervention.

R O Valdiserri 1, G D Cross 1, A R Gerber 1, R E Schwartz 1, T L Hearn 1
PMCID: PMC1405034  PMID: 2003631

Abstract

We surveyed laboratories to assess their capacity to perform T-lymphocyte immunophenotyping. Of the 1026 respondents, 279 located in 41 states and the District of Columbia performed this type of testing. Most laboratories were located in hospitals, reported a low weekly test volume, and indicated that it took 6-24 weeks for flow cytometer operators to become proficient. Many laboratories appear to have the capacity to perform additional CD4+ cell testing, but training additional operators may be necessary. The paucity of laboratories performing T-lymphocyte immunophenotyping in the public sector may affect referral patterns from that setting.

Full text

PDF
491

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Fahey J. L., Taylor J. M., Detels R., Hofmann B., Melmed R., Nishanian P., Giorgi J. V. The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1. N Engl J Med. 1990 Jan 18;322(3):166–172. doi: 10.1056/NEJM199001183220305. [DOI] [PubMed] [Google Scholar]
  2. Francis D. P., Anderson R. E., Gorman M. E., Fenstersheib M., Padian N. S., Kizer K. W., Conant M. A. Targeting AIDS prevention and treatment toward HIV-1-infected persons. The concept of early intervention. JAMA. 1989 Nov 10;262(18):2572–2576. [PubMed] [Google Scholar]
  3. Hofmann B., Wang Y. X., Cumberland W. G., Detels R., Bozorgmehri M., Fahey J. L. Serum beta 2-microglobulin level increases in HIV infection: relation to seroconversion, CD4 T-cell fall and prognosis. AIDS. 1990 Mar;4(3):207–214. [PubMed] [Google Scholar]
  4. Lang W., Perkins H., Anderson R. E., Royce R., Jewell N., Winkelstein W., Jr Patterns of T lymphocyte changes with human immunodeficiency virus infection: from seroconversion to the development of AIDS. J Acquir Immune Defic Syndr. 1989;2(1):63–69. [PubMed] [Google Scholar]
  5. McCarthy R. C., Fetterhoff T. J. Issues for quality assurance in clinical flow cytometry. Arch Pathol Lab Med. 1989 Jun;113(6):658–666. [PubMed] [Google Scholar]
  6. Phair J., Muñoz A., Detels R., Kaslow R., Rinaldo C., Saah A. The risk of Pneumocystis carinii pneumonia among men infected with human immunodeficiency virus type 1. Multicenter AIDS Cohort Study Group. N Engl J Med. 1990 Jan 18;322(3):161–165. doi: 10.1056/NEJM199001183220304. [DOI] [PubMed] [Google Scholar]
  7. Valdiserri R. O., Taylor R. N., Hearn T. L., Schalla W. O., Muir H. W. Centers for Disease Control perspective on quality assurance for human immunodeficiency virus type 1 antibody testing. Model Performance Evaluation Program. Arch Pathol Lab Med. 1990 Mar;114(3):263–267. [PubMed] [Google Scholar]
  8. Volberding P. A., Lagakos S. W., Koch M. A., Pettinelli C., Myers M. W., Booth D. K., Balfour H. H., Jr, Reichman R. C., Bartlett J. A., Hirsch M. S. Zidovudine in asymptomatic human immunodeficiency virus infection. A controlled trial in persons with fewer than 500 CD4-positive cells per cubic millimeter. The AIDS Clinical Trials Group of the National Institute of Allergy and Infectious Diseases. N Engl J Med. 1990 Apr 5;322(14):941–949. doi: 10.1056/NEJM199004053221401. [DOI] [PubMed] [Google Scholar]

Articles from American Journal of Public Health are provided here courtesy of American Public Health Association

RESOURCES