Skip to main content
NCBI home page
Immunology logoLink to Immunology
. 1972 Apr;22(4):565–571.

Effect of thoracic duct drainage on the primary and secondary immune responses in rats

induction of immunological tolerance

Mildred E Phillips, F Quagliata, G Jeanette Thorbecke
PMCID: PMC1407830  PMID: 5016234

Abstract

Rats were subjected to a 5-day period of lymph drainage from the thoracic duct. Although the primary response to sheep erythrocytes (SRBC), bovine serum albumin (BSA) and diphtheria toxoid (DT) was greatly diminished or abolished, the ability to give a secondary response in rats primed 6–12 months prior to the thoracic duct (TD) cannulation was not affected. Possible reasons for this marked difference between sensitivities of primary and secondary responses to TD drainage are discussed.

In addition it was shown that a 5-day period of TD drainage facilitated the induction of tolerance to DT.

Full text

PDF
565

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. JANKOVIC B. D., WAKSMAN B. H., ARNASON B. G. Role of the thymus in immune ractions in rats. I. The immunologic response to bovine serum albumin (antibody formation, Arthus reactivity, and delayed hypersensitivity) in rats thymectomized or splenectomized at various times after birth. J Exp Med. 1962 Aug 1;116:159–176. doi: 10.1084/jem.116.2.159. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Jacobson E. B., Thorbecke G. J. The proliferative and anamnestic antibody response of rabbit lymphoid cells in vitro. I. Immunological memory in the lymph nodes draining and contralateral to the site of a primary antigen injection. J Exp Med. 1969 Aug 1;130(2):287–297. doi: 10.1084/jem.130.2.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. MCGREGOR D. D., GOWANS J. L. SURVIVAL OF HOMOGRAFTS OF SKIN IN RATS DEPLETED OF LYMPHOCYTES BY CHRONIC DRAINAGE FROM THE THORACIC DUCT. Lancet. 1964 Mar 21;1(7334):629–632. doi: 10.1016/s0140-6736(64)91451-5. [DOI] [PubMed] [Google Scholar]
  4. MILLER J. F. Studies on mouse leukaemia. The role of the thymus in leukaemogenesis by cell-free leukaemic filtrates. Br J Cancer. 1960 Mar;14:93–98. doi: 10.1038/bjc.1960.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. MOLLER G., WIGZELL H. ANTIBODY SYNTHESIS AT THE CELLULAR LEVEL. ANTIBODY-INDUCED SUPPRESSION OF 19S AND 7S ANTIBODY RESPONSE. J Exp Med. 1965 Jun 1;121:969–989. doi: 10.1084/jem.121.6.969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Marchalonis J. J., Gledhill V. X. Elementary stochastic model for the induction of immunity and tolerance. Nature. 1968 Nov 9;220(5167):608–611. doi: 10.1038/220608a0. [DOI] [PubMed] [Google Scholar]
  7. Miller J. F., Osoba D. Current concepts of the immunological function of the thymus. Physiol Rev. 1967 Jul;47(3):437–520. doi: 10.1152/physrev.1967.47.3.437. [DOI] [PubMed] [Google Scholar]
  8. Mitchison N. A. The dosage requirements for immunological paralysis by soluble proteins. Immunology. 1968 Oct;15(4):509–530. [PMC free article] [PubMed] [Google Scholar]
  9. PERKINS E. H., ROBINSON M. A., MAKINODAN T. Agglutinin response, a function of cell number. J Immunol. 1961 May;86:533–537. [PubMed] [Google Scholar]
  10. Paul W. E., Thorbecke G. J., Siskind G. W., Benacerraf B. The effect of dose in tolerance induction on the subsequent response to a cross-reactive antigen. Immunology. 1969 Jul;17(1):85–92. [PMC free article] [PubMed] [Google Scholar]
  11. Pinnas J. L., Fitch F. W. Immunologic competence of thymectomized rats to several soluble and particulate antigens. Int Arch Allergy Appl Immunol. 1966;30(3):217–230. doi: 10.1159/000229807. [DOI] [PubMed] [Google Scholar]
  12. SCHWARTZ R., DAMESHEK W. Drug-induced immunological tolerance. Nature. 1959 Jun 13;183(4676):1682–1683. doi: 10.1038/1831682a0. [DOI] [PubMed] [Google Scholar]
  13. STAVITSKY A. B. Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. J Immunol. 1954 May;72(5):360–367. [PubMed] [Google Scholar]
  14. Shellam G. R. Mechanism of induction of immunological tolerance. VI. Tolerance induction following thoracic duct drainage or treatment with anti-lymphocyte serum. Immunology. 1969 Aug;17(2):267–280. [PMC free article] [PubMed] [Google Scholar]
  15. Smith J. B., Cunningham A. J., Lafferty K. J., Morris B. The role of the lymphatic system and lymphoid cells in the establishment of immunological memory. Aust J Exp Biol Med Sci. 1970 Feb;48(1):57–70. doi: 10.1038/icb.1970.6. [DOI] [PubMed] [Google Scholar]
  16. Thorbecke G. J., Benacerraf B. Tolerance in adult rabbits by repeated non-immunogenic doses of bovine serum albumin. Immunology. 1967 Aug;13(2):141–145. [PMC free article] [PubMed] [Google Scholar]
  17. Walker J. G., Siskind G. W. Studies on the control of antibody synthesis. Effect of antibody affinity upon its ability to suppress antibody formation. Immunology. 1968 Jan;14(1):21–28. [PMC free article] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES