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. 1972 May;22(5):859–869.

Cerebral vascular permeability and cellular infiltration in experimental allergic encephalomyelitis

S Leibowitz, Lesley Kennedy
PMCID: PMC1407847  PMID: 5021707

Abstract

Cerebral vascular permeability was measured in guinea-pigs developing experimental allergic encephalomyelitis (EAE). A sensitive double radio-isotope method was used which allowed the permeability changes to be measured independently of alterations in cerebral blood volume. The onset of the disease was accompanied by a striking increase in vascular permeability, but there was no evidence that this change preceded the entry of inflammatory cells into the brain and cord. Injection of serum from rabbits with EAE into normal guinea-pigs had no measurable effect on the cerebral vessels.

These findings are consistent with the view that EAE is a cell-mediated lesion and provide no support for the suggestion that the initial damage is due to circulating antibody.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARLOW C. F. A study of abnormal blood-brain permeability in experimental allergic encephalomyelitis. J Neuropathol Exp Neurol. 1956 Apr;15(2):196–207. doi: 10.1097/00005072-195604000-00005. [DOI] [PubMed] [Google Scholar]
  2. BORNSTEIN M. B., APPEL S. H. TISSUE CULTURE STUDIES OF DEMYELINATION. Ann N Y Acad Sci. 1965 Mar 31;122:280–286. doi: 10.1111/j.1749-6632.1965.tb20212.x. [DOI] [PubMed] [Google Scholar]
  3. Cutler R. W., Lorenzo A. V., Barlow C. F. Brain vascular permeability to I-125 gamma globulin and leukocytes in allergic encephalomyelitis. J Neuropathol Exp Neurol. 1967 Oct;26(4):558–571. doi: 10.1097/00005072-196710000-00004. [DOI] [PubMed] [Google Scholar]
  4. Hirano A., Dembitzer H. M., Becker N. H., Levine S., Zimmerman H. M. Fine structural alterations of the blood-brain barrier in experimental allergic encephalomyelitis. J Neuropathol Exp Neurol. 1970 Jul;29(3):432–440. doi: 10.1097/00005072-197007000-00007. [DOI] [PubMed] [Google Scholar]
  5. LAMPERT P., CARPENTER S. ELECTRON MICROSCOPIC STUDIES ON THE VASCULAR PERMEABILITY AND THE MECHANISM OF DEMYELINATION IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS. J Neuropathol Exp Neurol. 1965 Jan;24:11–24. doi: 10.1097/00005072-196501000-00002. [DOI] [PubMed] [Google Scholar]
  6. Leibowitz S. Cerebral vascular permeability in experimental allergic encephalomyelitis. Neuropatol Pol. 1969 Jul-Sep;7(3):303–309. [PubMed] [Google Scholar]
  7. Lisak R. P., Falk G. A., Heinze R. G., Kies M. W., Alvord E. C., Jr Dissociation of antibody production from disease suppression in the inhibition of allergic encephalomyelitis by myelin basic protein. J Immunol. 1970 Jun;104(6):1435–1446. [PubMed] [Google Scholar]
  8. Oldstone M. B., Dixon F. J. Immunohistochemical study of allergic encephalomyelitis. Am J Pathol. 1968 Feb;52(2):251–263. [PMC free article] [PubMed] [Google Scholar]
  9. Paterson P. Y. Experimental allergic encephalomyelitis and autoimmune disease. Adv Immunol. 1966;5:131–208. doi: 10.1016/s0065-2776(08)60273-4. [DOI] [PubMed] [Google Scholar]
  10. Wiener J., Lattes R. G., Spiro D. An electron microscopic study of leukocyte emigration and vascular permeability in tuberculin sensitivity. Am J Pathol. 1967 Mar;50(3):485–521. [PMC free article] [PubMed] [Google Scholar]

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