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. 1972 Sep;23(3):395–403.

A physiological mechanism preventing experimental allergic encephalitis

B Gerstl, C T Uyeda, H Hunt, L F Eng
PMCID: PMC1407941  PMID: 4139111

Abstract

Autoimmunization has been assumed to be a factor in the etiology of multiple sclerosis (MS). MS, however, almost never occurs subsequent to brain injury. Thus, it was hypothesized that human serum contains a component capable of neutralizing the effect of the encephalitogenic protein (EP) when released by injury. Small amounts of human or rabbit serum added to the EP-adjuvant inoculum prevented the disease in guinea-pigs. Neither albumin, IgG, β-lipoprotein, serum lipids, including phosphatidyl-serine, pre-albumin, nor circulating antibodies, are implicated in the preventive effect of human or rabbit serum. Antigenic competition or enzymatic cleavage of the EP do not appear to be the mechanism involved. Haemocyanin, hovever, is capable of preventing EAE when injected together with, or separately from, the EP.

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Selected References

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  1. ALVORD E. C., Jr, KIES M. W. Clinico-pathologic correlations in experimental allergic encephalomyelitis. II. Development of an index for quantitative assay of encephalitogenic activity of antigens. J Neuropathol Exp Neurol. 1959 Jul;18(3):447–457. doi: 10.1097/00005072-195907000-00007. [DOI] [PubMed] [Google Scholar]
  2. ALVORD E. C., Jr, SHAW C. M., HRUBY S., KIES M. W. ENCEPHALITOGEN-INDUCED INHIBITION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS: PREVENTION, SUPPRESSION AND THERAPY. Ann N Y Acad Sci. 1965 Mar 31;122:333–345. doi: 10.1111/j.1749-6632.1965.tb20218.x. [DOI] [PubMed] [Google Scholar]
  3. ALVORD E. C., SHAW C. M., FAHLBERG W. J., KIES M. W. AN ANALYSIS OF VARIOUS TYPES OF INHIBITION OF EXPERIMENTAL "ALLERGIC" ENCEPHALOMYELITIS IN THE GUINEA PIG. Z Immunitats Allergieforsch. 1964 Mar;126:217–227. [PubMed] [Google Scholar]
  4. Chao L. P., Einstein E. R. Localization of the active site through chemical modification of the encephalitogenic protein. J Biol Chem. 1970 Dec 10;245(23):6397–6403. [PubMed] [Google Scholar]
  5. Eng L. F., Chao F. C., Gerstl B., Pratt D., Tavaststjerna M. G. The maturation of human white matter myelin. Fractionation of the myelin membrane proteins. Biochemistry. 1968 Dec;7(12):4455–4465. doi: 10.1021/bi00852a042. [DOI] [PubMed] [Google Scholar]
  6. Eylar E. H., Caccam J., Jackson J. J., Westall F. C., Robinson A. B. Experimental allergic encephalomyelitis: synthesis of disease-inducing site of the basic protein. Science. 1970 Jun 5;168(3936):1220–1223. doi: 10.1126/science.168.3936.1220. [DOI] [PubMed] [Google Scholar]
  7. Falk G. A., Kies M. W., Alvord E. C., Jr Passive transfer of experimental allergic encephalomyelitis: mechanisms of suppression. J Immunol. 1969 Dec;103(6):1248–1253. [PubMed] [Google Scholar]
  8. Fauci A. S., Johnson J. S. Antigenic competition at the cellular level: response of rabbit lymph node cells to the trinitrophenyl and p-arsanilic hapTENS. J Immunol. 1971 May;106(5):1396–1398. [PubMed] [Google Scholar]
  9. Folds J. D., Stavitsky A. B. Enhanced protein and IgM and IgG antibody synthesis following an early second injection of hemocyanin into the rabbit. J Immunol. 1971 Feb;106(2):383–391. [PubMed] [Google Scholar]
  10. HOYER L. W., GOOD R. A., CONDIE R. M. Experimental allergic encephalomyelitis: the effect of 6-mercaptopurine. J Exp Med. 1962 Sep 1;116:311–327. doi: 10.1084/jem.116.3.311. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Jennings J. F., Oates C. M. Studies on the nonspecific depression of the immune response. J Exp Med. 1967 Oct 1;126(4):557–564. doi: 10.1084/jem.126.4.557. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. LEBARON F. N. THE NATURE OF THE LINKAGE BETWEEN PHOSPHOINOSITIDES AND PROTEINS IN BRAIN. Biochim Biophys Acta. 1963 Dec 27;70:658–669. doi: 10.1016/0006-3002(63)90810-2. [DOI] [PubMed] [Google Scholar]
  13. LEVINE S., STREBEL R., WENK E. J., HARMAN P. J. Suppression of experimental allergic encephalomyelitis by stress. Proc Soc Exp Biol Med. 1962 Feb;109:294–298. doi: 10.3181/00379727-109-27183. [DOI] [PubMed] [Google Scholar]
  14. LEVINE S., WENK E. J. Studies on the mechanism of altered susceptibility to experimental allergic encephalomyelitis. Am J Pathol. 1961 Oct;39:419–441. [PMC free article] [PubMed] [Google Scholar]
  15. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  16. Lamoureux G., Carnegie P. R., McPherson T. A. Experimental allergic encephalomyelitis--properties of an iodinated encephalitogenic polypeptide. Immunochemistry. 1967 Jul;4(4):273–281. doi: 10.1016/0019-2791(67)90189-9. [DOI] [PubMed] [Google Scholar]
  17. Levine S., Hoenig E. M., Kies M. W. Allergic encephalomyelitis: passive transfer prevented by encephalitogen. Science. 1968 Sep 13;161(3846):1155–1157. doi: 10.1126/science.161.3846.1155. [DOI] [PubMed] [Google Scholar]
  18. Levine S., Prineas J., Scheinberg L. C. Allergic encephalomyelitis: inhibition of cellular passive transfer by x-irradiation. Proc Soc Exp Biol Med. 1969 Jul;131(3):986–990. doi: 10.3181/00379727-131-34024. [DOI] [PubMed] [Google Scholar]
  19. Lisak R. P., Kies M. W. Mycobacterial suppression of delayed hypersensitivity in experimental allergic encephalomyelitis. Proc Soc Exp Biol Med. 1968 May;128(1):214–218. doi: 10.3181/00379727-128-32981. [DOI] [PubMed] [Google Scholar]
  20. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  21. McMaster P. R., Kyriakos M. The prevention of autoimmunity to the thyroid and allergic thyroiditis bantigenic competition. J Immunol. 1970 Nov;105(5):1201–1205. [PubMed] [Google Scholar]
  22. McPherson T. A., Marchalonis J. J., Lennon V. Binding of encephalitogenic basic protein by serum alpha-globulins. Immunology. 1970 Dec;19(6):929–933. [PMC free article] [PubMed] [Google Scholar]
  23. Niedieck B., Borriss E., Palacios O. Vergleichende Untersuchungen über die suppressive Wirkung von Anti-Lymphknotenseren auf die Experimentelle Allergische Encephalomyelitis (EAE) Z Immunitatsforsch Allerg Klin Immunol. 1969 May;137(5):458–473. [PubMed] [Google Scholar]
  24. OUCHTERLONY O. Diffusion-in-gel methods for immunological analysis. Prog Allergy. 1958;5:1–78. [PubMed] [Google Scholar]
  25. Palmer F. B., Dawson R. M. Complex-formation between triphosphoinositide and experimental allergic encephalitogenic protein. Biochem J. 1969 Mar;111(5):637–646. [PMC free article] [PubMed] [Google Scholar]
  26. Paterson P. Y., Hanson M. A. Cyclophosphamide inhibition of experimental allergic encephalomyelitis and cellular transfer of the disease in Lewis rats. J Immunol. 1969 Dec;103(6):1311–1316. [PubMed] [Google Scholar]
  27. Radovich J., Talmage D. W. Antigenic competition: cellular or humoral. Science. 1967 Oct 27;158(3800):512–514. doi: 10.1126/science.158.3800.512. [DOI] [PubMed] [Google Scholar]
  28. SCHEIDEGGER J. J. Une micro-méthode de l'immuno-electrophorèse. Int Arch Allergy Appl Immunol. 1955;7(2):103–110. [PubMed] [Google Scholar]
  29. Vogel C. L., Calabresi P. Enhanced suppression of experimental allergic encephalomyelitis by combination chemotherapy with duazomycin-A and 6-mercaptopurine. Proc Soc Exp Biol Med. 1969 May;131(1):251–256. doi: 10.3181/00379727-131-33852. [DOI] [PubMed] [Google Scholar]
  30. WAKSMAN B. H., ADAMS R. D. A comparative study of experimental allergic neuritis in the rabbit, guinea pig, and mouse. J Neuropathol Exp Neurol. 1956 Jul;15(3):293–334. doi: 10.1097/00005072-195607000-00005. [DOI] [PubMed] [Google Scholar]

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