Abstract
Epithelial cells are effective targets for lymphocyte stimulation in vitro. The magnitude of response to incompatible epithelial cells was equal to or slightly greater than that following incubation with lymphoid cells. Lymph node lymphocytes appear slightly more reactive to epithelia than comparable preparations of spleen cells. This model was used to study whether differentiation antigens of skin (Sk) which are not expressed on lymphoid cells can provoke an in vitro allograft reaction.
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Selected References
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- Adler W. H., Takiguchi T., Marsh B., Smith R. T. Cellular recognition by mouse lymphocytes in vitro. I. Definition of a new technique and results of stimulation by phytohemagglutinin and specific antigens. J Exp Med. 1970 Jun 1;131(6):1049–1078. doi: 10.1084/jem.131.6.1049. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Boyse E. A., Lance E. M., Carswell E. A., Cooper S., Old L. J. Rejection of skin allografts by radiation chimaeras: selective gene action in the specification of cell surface structure. Nature. 1970 Aug 29;227(5261):901–903. doi: 10.1038/227901a0. [DOI] [PubMed] [Google Scholar]
- Cooper S., Lance E. M. A serological method for detecting the surface antigens of epidermal cells. Transplantation. 1971 Jan;11(1):108–110. doi: 10.1097/00007890-197101000-00023. [DOI] [PubMed] [Google Scholar]
- Main R. K., Cochrum K. C., Jones M. J., Kountz S. L. Immunological potential of the in vitro mixed skin cell-leukocyte reaction. Nat New Biol. 1971 Jan 20;229(3):89–91. doi: 10.1038/newbio229089a0. [DOI] [PubMed] [Google Scholar]