Abstract
The increased intensity and prolongation of contact hypersensitivity reactions in animals treated 3 days prior to sensitization with 300 mg/kg cyclophosphamide (CY) has been investigated. No evidence has been found of increased activity of lymphoid tissue or non-specific skin reactivity following CY treatment. However there was evidence of normal T-lymphocyte function associated with reduced B-lymphocyte function. Partial reconstitution could be obtained by transplanting spleen and the effect of CY treatment could be partially reproduced by splenectomy following sensitization. It is suggested that a B-lymphocyte response to soluble antigen modulates a normal cell-mediated immune response during the development of chemical contact sensitivity in the healthy animal and that this could be blocked completely by treatment with CY prior to sensitization or partially by splenectomy after sensitization.
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Selected References
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- Blazkovec A. A., Sorkin E., Turk J. L. A study of the passive cellular transfer of local cutaneous hypersensitivity. I. Passive transfer of delayed hypersensitivity in inbred and outbred guinea-pigs. Int Arch Allergy Appl Immunol. 1965;27(5):289–303. doi: 10.1159/000229624. [DOI] [PubMed] [Google Scholar]
- Frey J. R., de Weck A. L., Geleick H. Studies on the induction of immunological tolerance by antigen in guinea-pigs already sensitized to dinitrochlorobenzene. Clin Exp Immunol. 1971 Jan;8(1):131–139. [PMC free article] [PubMed] [Google Scholar]
- Macher E., Chase M. W. Studies on the sensitization of animals with simple chemical compounds. XII. The influence of excision of allergenic depots on onset of delayed hypersensitivity and tolerance. J Exp Med. 1969 Jan 1;129(1):103–121. doi: 10.1084/jem.129.1.103. [DOI] [PMC free article] [PubMed] [Google Scholar]
- OORT J., TURK J. L. A HISTOLOGICAL AND AUTORADIOGRAPHIC STUDY OF LYMPH NODES DURING THE DEVELOPMENT OF CONTACT SENSITIVITY IN THE GUINEA-PIG. Br J Exp Pathol. 1965 Apr;46:147–154. [PMC free article] [PubMed] [Google Scholar]
- Parker D., Turk J. L. Studies on the ability of the subcellular fractions of epidermis, painted in vivo with DNFB, to cause contact sensitization in the guinea pig. Int Arch Allergy Appl Immunol. 1970;37(4):440–448. doi: 10.1159/000230806. [DOI] [PubMed] [Google Scholar]
- Reisfeld R. A., Hyslop N. E. Separation of 7S gamma-1-globulin, 7S gamma-2-globulin and macroglobulin guinea pig antibodies. Proc Soc Exp Biol Med. 1966 Feb;121(2):508–514. doi: 10.3181/00379727-121-30817. [DOI] [PubMed] [Google Scholar]
- TURK J. L. STUDIES ON THE MECHANISM OF ACTION OF METHOTREXATE AND CYCLOPHOSPHAMIDE ON CONTACT SENSITIVITY IN THE GUINEA PIG. Int Arch Allergy Appl Immunol. 1964;24:191–200. doi: 10.1159/000229459. [DOI] [PubMed] [Google Scholar]
- Turk J. L., Poulter L. W. Selective depletion of lymphoid tissue by cyclophosphamide. Clin Exp Immunol. 1972 Feb;10(2):285–296. [PMC free article] [PubMed] [Google Scholar]