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. 1972 Dec;23(6):937–946.

Clinical evaluation of serum immunoglobulin amoebiasis

A A Abioye, E A Lewis, H McFarlane
PMCID: PMC1407997  PMID: 4630782

Abstract

In eighty-nine adult Nigerians, with clinical and asymptomatic amoebiasis and in patients with conditions other than amoebiasis, serum concentrations of immunoglobulins (G, A and M) are presented as geometric mean values (mg/ml). Statistical analysis revealed a significant relationship between active symptomatic amoebiasis and raised IgG concentrations in all the groups studied except in pregnant and post-partum states. In contrast, analyses of the IgA and IgM data showed no significant correlation except in males with amoebic dysentery; and in males with amoebic liver abscess in which the respective immunoglobulins are significantly raised (Table 1). Estimation of immunoglobulin levels during a follow-up study in fifteen amoebiasis patients showed a tendency for IgG to fall appreciably with treatment of the disease.

The role of humoral immune responses in amoebiasis is discussed in the light of the low levels found in pregnancy and post-partum states, when the disease is known to be most severe.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ATCHLEY F. O., AUERNHEIMER A. H., WASLEY M. A. Precipitate patterns in agar gel with sera from human amebiasis and Entamoeba histolytica antigen. J Parasitol. 1963 Apr;49:313–315. [PubMed] [Google Scholar]
  2. Abioye A. A. Establishment and propagation of Ibadan strains of Entamoeba histolytica in vitro. Trans R Soc Trop Med Hyg. 1971;65(3):369–375. doi: 10.1016/0035-9203(71)90016-2. [DOI] [PubMed] [Google Scholar]
  3. Ali Khan Z., Meerovitch E. Serological characterization of gamma-M(19 S) and gamma-G(7 S) rabbit antibiodies in response to Entamoeba histolytica antigens. Can J Microbiol. 1968 Dec;14(12):1317–1323. doi: 10.1139/m68-221. [DOI] [PubMed] [Google Scholar]
  4. Boonpucknavig S., Nairn R. C. Serological diagnosis of amoebiasis by immunofluorescence. J Clin Pathol. 1967 Nov;20(6):875–878. doi: 10.1136/jcp.20.6.875. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Crabbé P. A., Heremans J. F. The distribution of immunoglobulin-containing cells along the human gastrointestinal tract. Gastroenterology. 1966 Sep;51(3):305–316. [PubMed] [Google Scholar]
  6. FAHEY J. L., MCKELVEY E. M. QUANTITATIVE DETERMINATION OF SERUM IMMUNOGLOBULINS IN ANTIBODY-AGAR PLATES. J Immunol. 1965 Jan;94:84–90. [PubMed] [Google Scholar]
  7. GELL P. G. The estimation of the individual human serum proteins by an immunological method. J Clin Pathol. 1957 Feb;10(1):67–71. doi: 10.1136/jcp.10.1.67. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Houba V., Allison A. C. M-antiglobulins (rheumatoid-factor-like globulins) and other gamma-globulins in relation to tropical parasitic infections. Lancet. 1966 Apr 16;1(7442):848–852. doi: 10.1016/s0140-6736(66)90186-3. [DOI] [PubMed] [Google Scholar]
  9. Jeanes A. L. Indirect fluorescent antibody test in diagnosis of hepatic amoebiasis. Br Med J. 1966 Jun 11;1(5501):1464–1464. doi: 10.1136/bmj.1.5501.1464. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Krupp I. M. Antibody response in intestinal and extraintestinal amebiasis. Am J Trop Med Hyg. 1970 Jan;19(1):57–62. doi: 10.4269/ajtmh.1970.19.57. [DOI] [PubMed] [Google Scholar]
  11. Lewis E. A., Antia A. U. Amoebic colitis: review of 295 cases. Trans R Soc Trop Med Hyg. 1969;63(5):633–638. doi: 10.1016/0035-9203(69)90183-7. [DOI] [PubMed] [Google Scholar]
  12. Maddison S. E., Kagan I. G., Norman L. Reactivity of human immunoglobulins in amebiasis. J Immunol. 1968 Jan;100(1):217–226. [PubMed] [Google Scholar]
  13. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  14. Milgram E. A., Healty G. R., Kagan I. G. Studies on the use of the indirect hemagglutination test in the diagnosis of amebiasis. Gastroenterology. 1966 May;50(5):645–649. [PubMed] [Google Scholar]
  15. NAKAMURA M. Inhibition of Entamoeba histolytica in vitro by specific antibody. Parasitology. 1959 May;49(1-2):104–107. doi: 10.1017/s0031182000026731. [DOI] [PubMed] [Google Scholar]
  16. Odunjo E. O. Pathological manifestations of amoebiasis in Nigerians. West Afr Med J Niger Pract. 1969 Aug;18(4):117–120. [PubMed] [Google Scholar]
  17. SOOTHILL J. F. Estimation of eight serum proteins by a gel diffusion precipitin technique. J Lab Clin Med. 1962 May;59:859–870. [PubMed] [Google Scholar]
  18. Savanat T., Chaicumpa W. Immunoelectrophoresis test for amoebiasis. Bull World Health Organ. 1969;40(3):343–353. [PMC free article] [PubMed] [Google Scholar]
  19. Tupasi T. E., Healy G. R. Adaptation of the Bozicevich Trichinella bentonite flocculation test for the diagnosis of amebiasis. Am J Trop Med Hyg. 1970 Jan;19(1):43–48. doi: 10.4269/ajtmh.1970.19.43. [DOI] [PubMed] [Google Scholar]

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