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. 1972 Dec;23(6):861–870.

Antibodies in delayed hypersensitive rats specifically desensitized by an intravenous injection of various antigen doses

Liisa Jokipii, A M M Jokipii
PMCID: PMC1408003  PMID: 4648853

Abstract

Rats with delayed hypersensitivity to bovine serum albumin (BSA) and diphtheria toxoid were specifically desensitized by an intravenous injection of BSA. The degree of desensitization was positively related to the dose of antigen. The 4-hour skin reactions to BSA were weaker, and the passive haemagglutinin titres, antigen-binding capacity and average avidity of the antibodies were lower in the desensitized rats than in controls. The suppression of delayed hypersensitivity was apparently not caused by increased circulating antibody activity, but by a cellular defect or a humoral blocking factor.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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