Abstract
In the antibody response to rabbit IgG in BALB/c mice, antigenic competition has been demonstrated between Fc and Fab'. Similar competition was found when a mixture of Fc and Fab' was used as antigen. In both cases the presence of Fc suppressed the antibody response to Fab'. Competition was demonstrable only in the primary antibody response. The effect on competition of varying the routes and the time course of administration of the antigens was investigated.
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Selected References
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- Amkraut A. A., Garvey J. S., Campbell D. H. Competition of haptens. J Exp Med. 1966 Sep 1;124(3):293–306. doi: 10.1084/jem.124.3.293. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Avrameas S., Ternynck T. Biologically active water-insoluble protein polymers. I. Their use for isolation of antigens and antibodies. J Biol Chem. 1967 Apr 10;242(7):1651–1659. [PubMed] [Google Scholar]
- Ben-Efraim S., Liacopoulos P. Inhibition, no-effect or enhancement of immune responses following injection of mixtures of immunogenic and non-immunogenic synthetic polypeptides. Immunology. 1967 May;12(5):517–524. [PMC free article] [PubMed] [Google Scholar]
- Binaghi R. A., Oriol R., Boussac-Aron Y. Immunogenicity of heterologous Fc and Fab immunoglobulin fragments in rabbits, guinea-pigs and rats. Immunology. 1967 Jul;13(1):63–69. [PMC free article] [PubMed] [Google Scholar]
- Brody N. I., Siskind G. W. Studies on antigenic competition. J Exp Med. 1969 Oct 1;130(4):821–832. doi: 10.1084/jem.130.4.821. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brody N. I., Walker J. G., Siskind G. W. Studies on the control of antibody synthesis. Interaction of antigenic competition and suppression of antibody formation by passive antibody on the immune response. J Exp Med. 1967 Jul 1;126(1):81–91. doi: 10.1084/jem.126.1.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cerottini J. C. An antigen-binding capacity test for human immunoglobulin G (IgG) fragments. J Immunol. 1968 Sep;101(3):433–438. [PubMed] [Google Scholar]
- Eidinger D., Khan S. A., Millar K. G. The effect of antigenic competition on various manifestations of humoral antibody formation and cellular immunity. J Exp Med. 1968 Nov 1;128(5):1183–1200. doi: 10.1084/jem.128.5.1183. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Henney C. S. The specificity of the early immune response. I. A comparison of the specificity of delayed hypersensitivity and humoral responses following immunization with human gammaG globulin. J Immunol. 1969 Sep;103(3):519–527. [PubMed] [Google Scholar]
- PORTER R. R. The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. Biochem J. 1959 Sep;73:119–126. doi: 10.1042/bj0730119. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Radovich J., Talmage D. W. Antigenic competition: cellular or humoral. Science. 1967 Oct 27;158(3800):512–514. doi: 10.1126/science.158.3800.512. [DOI] [PubMed] [Google Scholar]
- Schechter I. Antigenic competition between polypeptidyl determinants in normal and tolerant rabbits. J Exp Med. 1968 Feb 1;127(2):237–250. doi: 10.1084/jem.127.2.237. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schwartz H., Leskowitz S. Antigenic competition in the development of delayed hypersensitivity to the azobenzenearsonate group. Immunochemistry. 1969 May;6(3):503–506. doi: 10.1016/0019-2791(69)90311-5. [DOI] [PubMed] [Google Scholar]
- Taussig M. J. Bacteriophage linked assays for antibodies to protein antigens. Immunology. 1970 Mar;18(3):323–330. [PMC free article] [PubMed] [Google Scholar]
- Weigle W. O., High G. J. The effect of antigenic competition on antibody production to heterologous proteins, termination of immunologic unresponsiveness and induction of autoimmunity. J Immunol. 1967 Aug;99(2):392–398. [PubMed] [Google Scholar]