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. 1971 Jul;21(1):11–15.

Persistent formation of reagins in mice injected with low doses of ovalbumin

Eda M Vaz, N M Vaz, B B Levine
PMCID: PMC1408115  PMID: 5558030

Abstract

Immunization of mice with minute doses (0.1 μg) of ovalbumin in A1(OH)3 gel induced persistent synthesis of high titres (1:160, 1:320) of reaginic and IgG1 antibodies. Immunization with high doses of ovalbumin (100 μg) induced high IgG1 titres but only weak and transient formation of reagins. Inbred mouse strains differ widely in their immune responsiveness to low doses of ovalbumin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BINAGHI R. A., BENACERRAF B. THE PRODUCTION OF ANAPHYLACTIC ANTIBODY IN THE RAT. J Immunol. 1964 Jun;92:920–926. [PubMed] [Google Scholar]
  2. Bloch K. J. The anaphylactic antibodies of mammals including man. Prog Allergy. 1967;10:84–150. [PubMed] [Google Scholar]
  3. Clausen C. R., Munoz J., Bergman R. K. A reaginic type of antibody stimulated by extracts of Bordetella pertussis in inbred strains of mice. J Immunol. 1970 Feb;104(2):312–319. [PubMed] [Google Scholar]
  4. Ishizaka K., Ishizaka T. Human reaginic antibodies and immunoglobulin E. J Allergy. 1968 Dec;42(6):330–363. doi: 10.1016/0021-8707(68)90095-6. [DOI] [PubMed] [Google Scholar]
  5. Levine B. B., Vaz N. M. Effect of combinations of inbred strain, antigen, and antigen dose on immune responsiveness and reagin production in the mouse. A potential mouse model for immune aspects of human atopic allergy. Int Arch Allergy Appl Immunol. 1970;39(2-3):156–171. doi: 10.1159/000230343. [DOI] [PubMed] [Google Scholar]
  6. Lindqvist K. J. A unique class of rabbit immunoglobulins eliciting passive cutaneous anaphylaxis in homologous skin. Immunochemistry. 1968 Nov;5(6):525–542. doi: 10.1016/0019-2791(68)90089-x. [DOI] [PubMed] [Google Scholar]
  7. MOTA I. Mechanism of action of antigen-antibody complexes: their effect on mast cells. Nature. 1961 Aug 5;191:572–573. doi: 10.1038/191572a0. [DOI] [PubMed] [Google Scholar]
  8. McCamish J. A heat-labile skin sensitizing activity of mouse serum. Nature. 1967 Jun 17;214(5094):1228–1229. doi: 10.1038/2141228a0. [DOI] [PubMed] [Google Scholar]
  9. Mota I., Peixoto J. M. A skin-sensitizing and thermolabile antibody in the mouse. Life Sci. 1966 Sep;5(18):1723–1728. doi: 10.1016/0024-3205(66)90108-1. [DOI] [PubMed] [Google Scholar]
  10. Mota I., Wong D., Sadun E. H. Mouse homocytotropic antibodies. I. Specific differentiation between mouse 7S gamma 1 and mouse reagin-like antibodies. Life Sci. 1968 Dec 15;7(24):1289–1293. doi: 10.1016/0024-3205(68)90258-0. [DOI] [PubMed] [Google Scholar]
  11. Osler A. G., Lichtenstein L. M., Levy D. A. In vitro studies of human reaginic allergy. Adv Immunol. 1968;8:183–231. doi: 10.1016/s0065-2776(08)60467-8. [DOI] [PubMed] [Google Scholar]
  12. Prouvost-Danon A., Peixoto J. M., Javierre M. Q. Antigen-indued histamine release from peritoneal mast cells of mice producing reagin-like antibody. Immunology. 1968 Aug;15(2):271–286. [PMC free article] [PubMed] [Google Scholar]
  13. Revoltella R., Ovary Z. Reaginic antibody production in different mouse strains. Immunology. 1969 Jul;17(1):45–54. [PMC free article] [PubMed] [Google Scholar]
  14. Siskind G. W., Benacerraf B. Cell selection by antigen in the immune response. Adv Immunol. 1969;10:1–50. doi: 10.1016/s0065-2776(08)60414-9. [DOI] [PubMed] [Google Scholar]
  15. Uhr J. W., Möller G. Regulatory effect of antibody on the immune response. Adv Immunol. 1968;8:81–127. doi: 10.1016/s0065-2776(08)60465-4. [DOI] [PubMed] [Google Scholar]
  16. Vaz N. M., Levine B. B. Immune responses of inbred mice to repeated low doses of antigen: relationship to histocompatibility (H-2) type. Science. 1970 May 15;168(3933):852–854. doi: 10.1126/science.168.3933.852. [DOI] [PubMed] [Google Scholar]
  17. Zvaifler N. J., Becker E. L. Rabbit anaphylactic antibody. J Exp Med. 1966 May 1;123(5):935–950. doi: 10.1084/jem.123.5.935. [DOI] [PMC free article] [PubMed] [Google Scholar]

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