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. 1971 Aug;21(2):273–280.

Immunosuppressive activity of the pyrrolizidine alkaloid metabolite dehydroheliotridine

Jennifer J Percy, A E Pierce
PMCID: PMC1408124  PMID: 4937052

Abstract

Immunosuppression was observed with dehydroheliotridine (DHH), a recently isolated and identified metabolite of certain pyrrolizidine alkaloids. The primary response to sheep red blood cells (SRBC) and to influenza virus vaccine (IVV) was significantly depressed. The secondary response to SRBC was suppressed only if the DHH was given at the time of the secondary stimulus. DHH is active when given before or with the antigen but not when given 6 or 24 hours after the antigen. There was some evidence that the withdrawal of blood for haemagglutination inhibition tests derepressed the immunological response of DHH treated mice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AISENBERG A. C., WILES B. STUDIES ON THE SUPPRESSION OF IMMUNE RESPONSES BY THE PERIWINKLE ALKALOIDS VINCRISTINE AND VINBLASTINE. J Clin Invest. 1964 Dec;43:2394–2403. doi: 10.1172/JCI105114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cunningham A. J., Szenberg A. Further improvements in the plaque technique for detecting single antibody-forming cells. Immunology. 1968 Apr;14(4):599–600. [PMC free article] [PubMed] [Google Scholar]
  3. DE ST GROTH S. F., WITHELL J., LAFFERTY K. J. An improved assay method for neutralizing antibodies against influenza viruses. J Hyg (Lond) 1958 Sep;56(3):415–426. doi: 10.1017/s0022172400037906. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gabrielsen A. E., Good R. A. Chemical suppression of adaptive immunity. Adv Immunol. 1967;6:91–229. doi: 10.1016/s0065-2776(08)60522-2. [DOI] [PubMed] [Google Scholar]
  5. PETERSON J. E. EFFECTS OF THE PYRROLIZIDINE ALKALOID, LASIOCARPINE N-OXIDE, ON NUCLEAR AND CELL DIVISION IN THE LIVER RATS. J Pathol Bacteriol. 1965 Jan;89:153–171. doi: 10.1002/path.1700890117. [DOI] [PubMed] [Google Scholar]
  6. Syeklocha D., Siminovitch L., Till J. E., McCulloch E. A. The proliferative state of antigen-sensitive precursors of hemolysin-producing cells, determined by the use of the inhibitor, vinblastine. J Immunol. 1966 Mar;96(3):472–477. [PubMed] [Google Scholar]
  7. TALIAFERRO W. H., JAROSLOW B. N. The restoration of hemolysin formation in x-rayed rabbits by nucleic acid derivatives and antagonists of nucleic acid synthesis. J Infect Dis. 1960 Nov-Dec;107:341–350. doi: 10.1093/infdis/107.3.341. [DOI] [PubMed] [Google Scholar]

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