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. 1971 Aug;21(2):351–361.

Antigenic competition in vitro of spleen cells subjected to a graft-versus-host reaction

Olof Sjöberg
PMCID: PMC1408134  PMID: 4398350

Abstract

A graft-versus-host reaction was induced in F1 hybrid mice by the inoculation of spleen cells from one of the parental strains. One week later cultures for primary immunization in vitro against sheep red cells were initiated with the spleen cells of the recipients. It was found that the antibody response against sheep red cells was considerably inhibited in spleen cells from mice subjected to a graft-versus-host reaction as compared to the response of spleen cells from untreated mice. Furthermore, when spleen cells from animals subjected to a graft-versus-host reaction were cultured together with spleen cells from normal animals or animals preimmunized to sheep red cells, the antibody responses of the latter two cell populations were inhibited.

The relation between these findings and the antigenic competition phenomenon is discussed and it is suggested that antigenic competition is caused by an non-specific inhibition of the antibody response, caused by secretion of locally acting factors or by inhibition of normal cells by direct contact with `active' cells, stimulated by antigen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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