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. 1971 Nov;21(5):741–750.

The effect of synthetic double-stranded polyribonucleotides on haemopoietic colony-forming cells in vitro

T A McNeill
PMCID: PMC1408169  PMID: 5165564

Abstract

Addition of low concentrations of the synthetic double-stranded polynucleotides Poly I—Poly C and Poly AU to stimulated cultures of normal mouse bone marrow increased the number of macrophage colonies in the cultures. Double strandedness of the polynucleotides was essential for activity and they were active without the α-globulin which was previously shown to be a necessary co-factor in colony potentiation by some antigens. The evidence suggested that polynucleotides acted at the cell surface to make colony forming cells more responsive to colony stimulating factor.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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