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. 1971 Dec;21(6):1073–1078.

Heterogeneity of allergens from, and homocytotropic antibody to, a gastro-intestinal nematode of rabbits

G E Ford
PMCID: PMC1408255  PMID: 5129997

Abstract

More than one homocytotropic (reagin-like) antibody response in rabbits was demonstrated to a natural parasite, Trichostrongylus retortaeformis, a nematode which occurs only in the gastro-intestinal tract. The responses were detected by the homologous passive cutaneous anaphylaxis (PCA) reaction, three days after skin sensitization. Isoelectro-focusing of aqueous worm larval extract provided fractions in which more than one allergen was recognized. The separate allergen-homocytotropic antibody reactions were found with whole sera from different animals which had been infected by larvae of different ages, but it was not shown in this work whether this difference caused the separate antibody responses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Curtain C. C. A new immunoglobulin sub-class in the sheep. Immunology. 1969 Mar;16(3):373–380. [PMC free article] [PubMed] [Google Scholar]
  2. Goose J., Blair A. M. Passive cutaneous anaphylaxis in the rat, induced with two homologous reagin-like antibodies and its specific inhibition with disodium cromoglycate. Immunology. 1969 Jun;16(6):749–760. [PMC free article] [PubMed] [Google Scholar]
  3. Henson P. M., Cochrane C. G. Immunological induction of increased vascular permeability. I. A rabbit passive cutaneous anaphylactic reaction requiring complement, platelets, and neutrophils. J Exp Med. 1969 Jan 1;129(1):153–165. doi: 10.1084/jem.129.1.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hogarth-Scott R. S. Homocytotropic antibody in sheep. Immunology. 1969 Apr;16(4):543–548. [PMC free article] [PubMed] [Google Scholar]
  5. Hogarth-Scott R. S., Johansson S. G., Bennich H. Antibodies to Toxocara in the sera of visceral larva migrans patients: the significance of raised levels of IgE. Clin Exp Immunol. 1969 Dec;5(6):619–625. [PMC free article] [PubMed] [Google Scholar]
  6. Hogarth-Scott R. S. Rabbit reagin-like antibodies. Int Arch Allergy Appl Immunol. 1967;32(2):201–207. doi: 10.1159/000229928. [DOI] [PubMed] [Google Scholar]
  7. Hogarth-Scott R. S. The molecular weight range of nematode allergens. Immunology. 1967 Nov;13(5):535–537. [PMC free article] [PubMed] [Google Scholar]
  8. Ishizaka K., Ishizaka T. Biological function of gamma E antibodies and mechanisms of reaginic hypersensitivity. Clin Exp Immunol. 1970 Jan;6(1):25–42. [PMC free article] [PubMed] [Google Scholar]
  9. Ishizaka K., Ishizaka T. Identification of gamma-E-antibodies as a carrier of reaginic activity. J Immunol. 1967 Dec;99(6):1187–1198. [PubMed] [Google Scholar]
  10. Ivey M. H., Slanga R. An evaluation of passive cutaneous anaphylactic reactions with Trichinella and Toxocara antibody-antigen systems. Am J Trop Med Hyg. 1965 Nov;14(6):1052–1056. doi: 10.4269/ajtmh.1965.14.1052. [DOI] [PubMed] [Google Scholar]
  11. Jones V. E., Ogilvie B. M. Reaginic antibodies and immunity to Nippostrongylus brasiliensis in the rat. II. Some properties of the antibodies and antigens. Immunology. 1967 May;12(5):583–597. [PMC free article] [PubMed] [Google Scholar]
  12. MOTA I. THE MECHANISM OF ANAPHYLAXIS. I. PRODUCTION AND BIOLOGICAL PROPERTIES OF 'MAST CELL SENSITIZING' ANTIBODY. Immunology. 1964 Nov;7:681–699. [PMC free article] [PubMed] [Google Scholar]
  13. Mota I., Sadun E. H., Bradshaw R. M., Gore R. W. The immunological response of mice infected with Trichinella spiralis. Biological and physico-chemical distinction of two homocytotropic antibodies. Immunology. 1969 Jan;16(1):71–81. [PMC free article] [PubMed] [Google Scholar]
  14. OGILVIE B. M. REAGIN-LIKE ANTIBODIES IN ANIMALS IMMUNE TO HELMINTH PARASITES. Nature. 1964 Oct 3;204:91–92. doi: 10.1038/204091a0. [DOI] [PubMed] [Google Scholar]
  15. OVARY Z. Immediate reactions in the skin of experimental animals provoked by antibody-antigen interaction. Prog Allergy. 1958;5:459–508. [PubMed] [Google Scholar]
  16. Ogilvie B. M. Reagin-like antibodies in rats infected with the nematode parasite Nippostrongylus brasiliensis. Immunology. 1967 Feb;12(2):113–131. [PMC free article] [PubMed] [Google Scholar]
  17. Onoue K., Yagi Y., Pressman D. Isolation of rabbit IgA antihapten antibody and demonstration of skin-sensitizing activity in homologous skin. J Exp Med. 1966 Jan 1;123(1):173–190. doi: 10.1084/jem.123.1.173. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Parish W. E. Short-term anaphylactic IgG antibodies in human sera. Lancet. 1970 Sep 19;2(7673):591–592. doi: 10.1016/s0140-6736(70)90170-4. [DOI] [PubMed] [Google Scholar]
  19. Reid R. T., Minden P., Farr R. S. Reaginic activity associated with IgG immunoglobulin. J Exp Med. 1966 May 1;123(5):845–858. doi: 10.1084/jem.123.5.845. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Sadun E. H., Duxbury R. E., Gore R. W., Stechschulte D. J. Homologous passive cutaneous anaphylactic and fluorescent antibody reactions in rabbits infected with Dirofilaria uniformis. J Infect Dis. 1967 Oct;117(4):317–326. doi: 10.1093/infdis/117.4.317. [DOI] [PubMed] [Google Scholar]
  21. Sadun E. H., Mota I., Gore R. W. Demonstration of homocytotropic reaginlike antibodies in mice and rabbits infected with Trichinella spiralis. J Parasitol. 1968 Aug;54(4):814–821. [PubMed] [Google Scholar]
  22. Wilson R. J. Homocytotropic antibody response to the nematode Nippostrongylus brasiliensis in the rat--studies on the worm antigen. J Parasitol. 1967 Aug;53(4):752–762. [PubMed] [Google Scholar]
  23. Wilson R. J., Jones V. E., Leskowitz S. Thymectomy and anaphylactic antibody in rats infected with Nippostrongylus brasiliensis. Nature. 1967 Jan 28;213(5074):398–399. doi: 10.1038/213398a0. [DOI] [PubMed] [Google Scholar]

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