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. 1967 Mar;12(3):275–283.

Inhibition of the anti-globulin reaction by human immunoglobulin G and its fragments

P J Grob, H C Isliker, T Webb
PMCID: PMC1409112  PMID: 4164031

Abstract

The specificities of antibodies involved in the agglutination of anti-D sensitized human red cells was studied using IgG and its fragments Fc and Fab as inhibitors. It was shown that commercial anti-globulin sera and specific sheep anti-IgG serum react with the antigenic groups common to IgG and Fc. Anti-Fab serum on the other hand agglutinated anti-D sensitized red cells by reacting with the antigenic groups common to IgG and Fab. This result is interpreted to mean that antibodies reacting with Fab have different specificities depending on whether IgG or Fab was used as antigen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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