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. 1967 May;12(5):517–524.

Inhibition, no-effect or enhancement of immune responses following injection of mixtures of immunogenic and non-immunogenic synthetic polypeptides

S Ben-Efraim, P Liacopoulos
PMCID: PMC1409128  PMID: 6022088

Abstract

The phenomenon of antigenic competition has been investigated by the use of synthetic compounds and guinea-pigs of inbred strain 2 as experimental animals. The effect of addition to the immunizing mixture of immunogenic and non-immunogenic synthetic compounds has been studied.

Antigenic competition has been demonstrated between the synthetic antigen 252,p(Tyr,Glu,Lys) and DNP-p(Lys) or 28,pdlAla-p(Tyr,Glu)--pLys.

The non-immunogenic compounds 251,p(dTyr,dGlu,dLys), 33,pTyr-pdlAla--pLys, and p(Tyr) have been found respectively to inhibit, enhance, or not affect the immune response to 252,p(Tyr,Glu,Lys). Two weak antigens, namely 509,p(Tyr,Glu,)-pdlAla--pLys and p(Lys) also enhanced the response to 252,p(Tyr,Glu,Lys). Possible explanations for these findings are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BEN-EFRAIM S., FUCHS S., SELA M. PASSIVE CUTANEOUS ANAPHYLAXIS IN THE GUINEA-PIG WITH RABBIT ANTIBODIES AGAINST SYNTHETIC POLYPEPTIDES. Immunology. 1964 Mar;7:142–149. [PMC free article] [PubMed] [Google Scholar]
  2. Ben-Efraim S., Liacopoulos P. Compétition entre stéréoisomères D et L d'antigènes synthétiques au cours de l'induction de l'hypersensibilité retardée. C R Acad Sci Hebd Seances Acad Sci D. 1965 Nov 29;261(22):4918–4921. [PubMed] [Google Scholar]
  3. Borek F., Stupp Y., Fuchs S., Sela M. Relation between optical configuration and immunogenicity of synthetic polypeptides. Biochem J. 1965 Sep;96(3):577–582. doi: 10.1042/bj0960577. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Green I., Paul W. E., Benacerraf B. The behavior of hapten-poly-L-lysine conjugates as complete antigens in genetic responder and as haptens in nonresponder guinea pigs. J Exp Med. 1966 May 1;123(5):859–879. doi: 10.1084/jem.123.5.859. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. McDevitt H. O., Sela M. Genetic control of the antibody response. I. Demonstration of determinant-specific differences in response to synthetic polypeptide antigens in two strains of inbred mice. J Exp Med. 1965 Sep 1;122(3):517–531. doi: 10.1084/jem.122.3.517. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. NEVEU T. ETUDE DE LA COMP'ETITION DES ANTIG'ENES CHEZ LE COBAYE ADULTE. EFFET SUR L'INDUCTION DE L'HYPERSENSIBILIT'E RETARD'EE ET SUR LA FORMATION D'ANTICORPS ENVERS UNE PROT'EINE HOMOLOGUE CONJUGU'EE AVEC LE CHLORURE DE PICRYLE. Ann Inst Pasteur (Paris) 1964 Sep;107:320–339. [PubMed] [Google Scholar]
  7. SAGE H. J., DEUTSCH G. F., FASMAN G. D., LEVINE L. THE SEROLOGICAL SPECIFICITY OF THE POLY-ALANINE IMMUNE SYSTEM. Immunochemistry. 1964 Jun;1:133–144. doi: 10.1016/0019-2791(64)90077-1. [DOI] [PubMed] [Google Scholar]
  8. SELA M., FUCHS S., ARNON R. Studies on the chemical basis of the antigenicity of proteins. 5. Synthesis, characterization and immunogenicity of some multichain and linear polypeptides containing tyrosine. Biochem J. 1962 Oct;85:223–235. doi: 10.1042/bj0850223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Schechter I. Competition of antigenic determinants. Biochim Biophys Acta. 1965 Jun 15;104(1):303–305. doi: 10.1016/0304-4165(65)90254-0. [DOI] [PubMed] [Google Scholar]
  10. Schechter I., Sela M. Preferential immune response to D-amino acid residues in poly-DL-amino acid determinants. Biochim Biophys Acta. 1965 Jun 15;104(1):301–302. doi: 10.1016/0304-4165(65)90253-9. [DOI] [PubMed] [Google Scholar]
  11. Schlossman S. F., Ben-Efraim S., Yaron A., Sober H. A. Immunochemical studies on the antigenic determinants required to elicit delayed and immediate hypersensitivity reactions. J Exp Med. 1966 Jun 1;123(6):1083–1095. doi: 10.1084/jem.123.6.1083. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Sela M. Immunological studies with synthetic polypeptides. Adv Immunol. 1966;5:29–129. doi: 10.1016/s0065-2776(08)60272-2. [DOI] [PubMed] [Google Scholar]

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