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. 1967 Jul;13(1):39–48.

The biological effects of anti-thyroid antibodies

Thyroid eosinophilia following passive transfer of anti-thyroglobulin antibody

G C Sharp, H H Wortis, Beverly Dunmore
PMCID: PMC1409145  PMID: 4165632

Abstract

Guinea-pigs that received a passive transfer of rabbit antiserum to guinea-pig thyroglobulin developed an eosinophilic infiltrate of the thyroid. The infiltrate varied in intensity in different guinea-pigs, developed over a 1–24-hour period, and resolved in 4–9 days. The antibody that was injected was localized to the interstitial areas of the thyroid gland. It is proposed that thyroglobulin is also present in the interstitial areas either normally or as a result of the antiserum injection and that the eosinophils appeared in response to the presence of thyroglobulin—anti-thyroglobulin complexes in these areas.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALLANSMITH M., GOIHMAN-YAHR M., BUELL D. N. DEMONSTRATION OF GAMMA-2 GLOBULIN IN HUMAN SKIN. J Allergy. 1964 Jul-Aug;35:313–321. doi: 10.1016/0021-8707(64)90094-2. [DOI] [PubMed] [Google Scholar]
  2. ARCHER G. T., HIRSCH J. G. MOTION PICTURE STUDIES ON DEGRANULATION OF HORSE EOSINOPHILS DURING PHAGOCYTOSIS. J Exp Med. 1963 Aug 1;118:287–294. doi: 10.1084/jem.118.2.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Assem E. S., Trotter W. R., Belyavin G. Thyroglobulin and thyroglobulin antibodies in the serum of normal adults. Immunology. 1965 Jul;9(1):21–29. [PMC free article] [PubMed] [Google Scholar]
  4. EDELHOCH H. The properties of thyroglobulin. I. The effects of alkali. J Biol Chem. 1960 May;235:1326–1334. [PubMed] [Google Scholar]
  5. HJORT T., PEDERSEN G. T. Thyroid antibodies and "thyroglobulin" in the serum in pregnant and parturient women and in newborn infants. Lancet. 1962 Aug 11;2(7250):259–263. doi: 10.1016/s0140-6736(62)90170-8. [DOI] [PubMed] [Google Scholar]
  6. IRVINE W. J. The cytotoxic factor in thyroid disease. Scott Med J. 1960 Dec;5:511–522. doi: 10.1177/003693306000501202. [DOI] [PubMed] [Google Scholar]
  7. KOFFLER D., PARONETTO F. SEROLOGIC AND IMMUNOFLUORESCENT STUDIES OF HUMORAL ANTIBODY AND GAMMA-GLOBULIN LOCALIZATION IN EXPERIMENTAL AUTOIMMUNE THYROIDITIS. J Immunol. 1965 Mar;94:329–336. [PubMed] [Google Scholar]
  8. LITT M. EOSINOPHILS AND ANTIGEN-ANTIBODY REACTIONS. Ann N Y Acad Sci. 1964 Aug 27;116:964–985. doi: 10.1111/j.1749-6632.1964.tb52562.x. [DOI] [PubMed] [Google Scholar]
  9. LITT M. STUDIES IN EXPERIMENTAL EOSINOPHILIA. VI. UPTAKE OF IMMUNE COMPLEXES BY EOSINOPHILS. J Cell Biol. 1964 Nov;23:355–361. doi: 10.1083/jcb.23.2.355. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. LITT M. Studies in experimental eosinophilia. III. The induction of peritoneal eosinophilia by the passive transfer of serum antibody. J Immunol. 1961 Nov;87:522–529. [PubMed] [Google Scholar]
  11. LITT M. Studies in experimental eosinophilia. V. Eosinophils in lynph nodes of guinea pigs following primary antigenic stimulation. Am J Pathol. 1963 May;42:529–549. [PMC free article] [PubMed] [Google Scholar]
  12. MCMASTER P. R., LERNER E. M., 2nd, EXUM E. D. The relationship of delayed hypersensitivity and circulating antibody to experimental allergic thyroditis in inbred guinea pigs. J Exp Med. 1961 Apr 1;113:611–624. doi: 10.1084/jem.113.4.611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. MIESCHER P., GORSTEIN F., BENACERRAF B., GELL P. G. Studies on the pathogenesis of experimental immune thyroiditis. Proc Soc Exp Biol Med. 1961 May;107:12–16. doi: 10.3181/00379727-107-26519. [DOI] [PubMed] [Google Scholar]
  14. PULVERTAFT R. J., DONIACH D., ROITT I. M. The cytotoxic factor in Hashimoto's disease and its incidence in other thyroid diseases. Br J Exp Pathol. 1961 Oct;42:496–503. [PMC free article] [PubMed] [Google Scholar]
  15. ROITT I. M., DONIACH D. Human autoimmune thyroiditis: serological studies. Lancet. 1958 Nov 15;2(7055):1027–1033. doi: 10.1016/s0140-6736(58)90530-0. [DOI] [PubMed] [Google Scholar]
  16. ROSE N. R., WITEBSKY E. Studies on organ specificity. V. Changes in the thyroid glands of rabbits following active immunization with rabbit thyroid extracts. J Immunol. 1956 Jun;76(6):417–427. [PubMed] [Google Scholar]
  17. SABESIN S. M. A function of the eosinophil: phagocytosis of antigen-antibody complexes. Proc Soc Exp Biol Med. 1963 Mar;112:667–670. doi: 10.3181/00379727-112-28134. [DOI] [PubMed] [Google Scholar]
  18. SCHEIDEGGER J. J. Une micro-méthode de l'immuno-electrophorèse. Int Arch Allergy Appl Immunol. 1955;7(2):103–110. [PubMed] [Google Scholar]
  19. SCLARE G., TAYLOR G. Experimental thyroiditis and the placental transfer of auto-antibodies. J Pathol Bacteriol. 1961 Jul;82:29–44. doi: 10.1002/path.1700820106. [DOI] [PubMed] [Google Scholar]
  20. SPEIRS R. S. A theory of antibody formation involving eosinophils and reticuloendothelial cells. Nature. 1958 Mar 8;181(4610):681–682. doi: 10.1038/181681a0. [DOI] [PubMed] [Google Scholar]
  21. STAVITSKY A. B. Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. J Immunol. 1954 May;72(5):360–367. [PubMed] [Google Scholar]
  22. TERPLAN K. L., WITEBSKY E., ROSE N. R., PAINE J. R., EGAN R. W. Experimental thyroiditis in rabbits, guinea pigs and dogs, following immunization with thyroid extracts of their own and of heterologous species. Am J Pathol. 1960 Feb;36:213–239. [PMC free article] [PubMed] [Google Scholar]

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