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. 1967 Jul;13(1):9–17.

Production of hapten-specific unresponsiveness in adult guinea-pigs by prior injection of monovalent conjugates

S Leskowitz
PMCID: PMC1409153  PMID: 6027785

Abstract

Adult guinea-pigs injected with a small monovalent conjugate of arsanilic acid, from 2 weeks before to the day of immunization, with hapten-conjugate in adjuvant show a profound depression of hapten-specific delayed sensitivity. The same conjugate given 1–2 weeks after immunization is no longer effective. More than 95 per cent of the intravenously administered monovalent conjugate was found to be excreted in 5 days. Passively administered antibody was without effect on the subsequent development of the hapten-specific delayed sensitivity. These observations are consistent with the hypothesis that the non-immunizing intravenous injection of monovalent conjugate is paralysing to precursor cells if given first, but that once these cells are engaged by adjuvant immunization they are no longer repressible but only transiently inhibitable, as long as high concentrations of monovalent conjugate remain in the circulation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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