Skip to main content
NCBI home page
Immunology logoLink to Immunology
. 1967 Oct;13(4):373–380.

Failure to induce tolerance to rat tissue antigens

D M Weir, R N Pinckard
PMCID: PMC1409220  PMID: 6055753

Abstract

Rats subjected to an intensive injection schedule from birth for 5 weeks with rat liver antigen failed to show immunological tolerance with respect to the production of heat-labile and heat-stable high molecular weight antibody when challenged with liver antigen or carbon tetrachloride.

It is suggested that particulate subcellular components of the animals' own tissues, like foreign particulate antigens, may not readily induce tolerance and that this may explain the finding of anti-tissue antibodies in various human diseases particularly following tissue breakdown.

Full text

PDF
373

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Altemeier W. A., 3rd, Robbins J. B., Smith R. T. Quantitative studies of the immunoglobulin sequence in the response of the rabbit to a somatic antigen. J Exp Med. 1966 Sep 1;124(3):443–460. doi: 10.1084/jem.124.3.443. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ehrenfeld E. N., Gery I., Davies A. M. Specific antibodies in heart-disease. Lancet. 1961 May 27;1(7187):1138–1141. doi: 10.1016/s0140-6736(61)92066-9. [DOI] [PubMed] [Google Scholar]
  3. FELDMAN M., YAFFE D. Production of organ-specific antibodies following an induction of tolerance to antigens of heterologous organs. Nature. 1957 Jun 29;179(4574):1353–1354. doi: 10.1038/1791353a0. [DOI] [PubMed] [Google Scholar]
  4. GERY I., DAVIES A. M., LAZAROV E. IMMUNITY AND IMMUNOTOLERANCE TO BOVINE HEART ANTIGENS IN THE RAT. Immunology. 1964 Mar;7:182–192. [PMC free article] [PubMed] [Google Scholar]
  5. KRAMER N. C., WATT M. F., HOWE J. H., PAR RISH A. E. Circulating antihuman kidney antibodies in human renal disease. Am J Med. 1961 Jan;30:39–45. doi: 10.1016/0002-9343(61)90062-6. [DOI] [PubMed] [Google Scholar]
  6. MACKAY I. R., GAJDUSEK D. C. An autoimmune reaction against human tissue antigens in certain acute and chronic diseases. II. Clinical correlations. AMA Arch Intern Med. 1958 Jan;101(1):30–46. doi: 10.1001/archinte.1958.00260130044004. [DOI] [PubMed] [Google Scholar]
  7. PATERSON P. Y., COIA E. M., JACOBS A. F. COMPLEMENT-FIXING ANTIBRAIN ANTIBODIES AND ALLERGIC ENCEPHALOMYELITIS. I. CHARACTERIZATION OF THE ANTIBODIES. Ann N Y Acad Sci. 1965 Mar 31;122:256–265. doi: 10.1111/j.1749-6632.1965.tb20209.x. [DOI] [PubMed] [Google Scholar]
  8. PATERSON P. Y. Studies of immunological tolerance to nervous tissue in rats. Ann N Y Acad Sci. 1958 Oct 7;73(3):811–818. doi: 10.1111/j.1749-6632.1959.tb40860.x. [DOI] [PubMed] [Google Scholar]
  9. Pinckard R. N., Weir D. M. Antibodies against the mitochondrial fraction of liver after toxic liver damage in rats. Clin Exp Immunol. 1966 Jan;1(1):33–43. [PMC free article] [PubMed] [Google Scholar]
  10. WEIR D. M. IMMUNOLOGICAL REACTIONS AFTER TISSUE DAMAGE. Lancet. 1964 Apr 4;1(7336):749–750. doi: 10.1016/s0140-6736(64)92855-7. [DOI] [PubMed] [Google Scholar]
  11. WEIR D. M. LIVER AUTOANTIBODIES IN THE RAT. Immunology. 1963 Nov;6:581–591. [PMC free article] [PubMed] [Google Scholar]
  12. WYTTENBACH C. R. Immunological tolerance induced in rabbits toward saline homogenates of chicken spleen and liver. Dev Biol. 1960 Apr;2:173–195. doi: 10.1016/0012-1606(60)90005-1. [DOI] [PubMed] [Google Scholar]
  13. Weir D. M., Pinckard R. N., Elson C. J., Suckling D. E. Naturally occurring anti-tissue antibodies in rat sera. Clin Exp Immunol. 1966 Oct;1(4):433–442. [PMC free article] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES