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. 1967 Dec;13(6):585–595.

The immune response to heterologous red cells in mice

II. Antibody formation to red cells from species taxonomically related to sheep or mouse

F M Dietrich, P Dukor
PMCID: PMC1409246  PMID: 6065017

Abstract

An attempt was made to establish the relative immunogenicity of various heterologous erythrocytes in the mouse. The immune response to multispecies red cells was examined by zone centrifugation of the antibodies, and by studying cross-reactivity between the varioys erythrocytes, time-course of haemagglutinin formation, and finally, antigen dose—antibody response relationships. As compared to sheep erythrocytes, goat erythrocytes were found to have a greatly reduced agglutinability, which merely simulated a reduced immunogenicity. However, erythrocytes from gerbil and hamster proved to be genuinely weaker antigens in the mouse. For alkylating agents, anti-metabolites and anti-mitotic compounds the drug-sensitivity of the immune response to cells of different antigenicity was not altered.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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