Skip to main content
NCBI home page
Immunology logoLink to Immunology
. 1968 Jan;14(1):127–138.

Immunity to malaria: the antibody response to antigenic variation by Plasmodium knowlesi

I N Brown, K N Brown, L A Hills
PMCID: PMC1409250  PMID: 4965829

Abstract

Monkey erythrocytes infected with schizonts of Plasmodium knowlesi are agglutinated when mixed with serum taken from chronically infected monkeys (Eaton, 1938). This reaction has proved highly specific and capable of distinguishing antigenic variants of one strain. Chronic infections of P. knowlesi in rhesus monkeys are maintained by a succession of antigenically distinct populations, each population stimulating a specific agglutinin response. Additional agglutinins which are not variant specific are found at low titre in sera taken after an infection has persisted for a month or more. The possible relevance of these observations to protective immunity is discussed.

Full text

PDF
127

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AZEN A. E., SCHILLING R. F. EXTRAVASCULAR DESTRUCTION OF ACETYLPHENYLHYDRAZINE-DAMAGED ERYTHROCYTES IN THE RAT. J Lab Clin Med. 1964 Jan;63:122–136. [PubMed] [Google Scholar]
  2. Berken A., Benacerraf B. Properties of antibodies cytophilic for macrophages. J Exp Med. 1966 Jan 1;123(1):119–144. doi: 10.1084/jem.123.1.119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brent L., Medawar P. B. Cellular immunity and the homograft reaction. Br Med Bull. 1967 Jan;23(1):55–60. doi: 10.1093/oxfordjournals.bmb.a070517. [DOI] [PubMed] [Google Scholar]
  4. Brown K. N., Brown I. N. Immunity to malaria: antigenic variation in chronic infections of Plasmodium knowlesi. Nature. 1965 Dec 25;208(5017):1286–1288. doi: 10.1038/2081286a0. [DOI] [PubMed] [Google Scholar]
  5. CHIN W., CONTACOS P. G., COATNEY G. R., KIMBALL H. R. A NATURALLY ACQUITED QUOTIDIAN-TYPE MALARIA IN MAN TRANSFERABLE TO MONKEYS. Science. 1965 Aug 20;149(3686):865–865. doi: 10.1126/science.149.3686.865. [DOI] [PubMed] [Google Scholar]
  6. COX H. W. A study of relapse Plasmodium berghei infections isolated from white mice. J Immunol. 1959 Mar;82(3):209–214. [PubMed] [Google Scholar]
  7. CROME P., MOLLISON P. L. SPLENIC DESTRUCTION OF RH-SENSITIZED, AND OF HEATED RED CELLS. Br J Haematol. 1964 Apr;10:137–154. doi: 10.1111/j.1365-2141.1964.tb00689.x. [DOI] [PubMed] [Google Scholar]
  8. GRAY A. R. The influence of antibody on serological variation in Trypanosoma brucei. Ann Trop Med Parasitol. 1962 Apr;56:4–13. doi: 10.1080/00034983.1962.11686083. [DOI] [PubMed] [Google Scholar]
  9. HOLZBACH R. T., SHIPLEY R. A., CLARK R. E., CHUDZIK E. B. INFLUENCE OF SPLEEN SIZE AND PORTAL PRESSURE ON ERYTHROCYTE SEQUESTRATION. J Clin Invest. 1964 Jun;43:1125–1135. doi: 10.1172/JCI104997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Krebs H. A., Eggleston L. V. The oxidation of pyruvate in pigeon breast muscle. Biochem J. 1940 Mar;34(3):442–459. doi: 10.1042/bj0340442. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mackaness G. B. The relationship of delayed hypersensitivity to acquired cellular resistance. Br Med Bull. 1967 Jan;23(1):52–54. doi: 10.1093/oxfordjournals.bmb.a070516. [DOI] [PubMed] [Google Scholar]
  12. SINGH J., RAY A. P., NAIR C. P. Isolation of a new strain of Plasmodium knowlesi. Nature. 1953 Jul 18;172(4368):122–122. doi: 10.1038/172122a0. [DOI] [PubMed] [Google Scholar]
  13. TALIAFERRO W. H., TALIAFERRO L. G. The dynamics of hemolysin formation in intact and splenectomized rabbits. J Infect Dis. 1950 Jul-Aug;87(1):37–62. doi: 10.1093/infdis/87.1.37. [DOI] [PubMed] [Google Scholar]
  14. ULTMANN J. E., GORDON C. S. THE REMOVAL OF IN VITRO DAMAGED ERYTHROCYTES FROM THE CIRCULATION OF NORMAL AND SPLENECTOMIZED RATS. Blood. 1965 Jul;26:49–62. [PubMed] [Google Scholar]
  15. VISCHER W. A., SUTER E. Intracellular multiplication of Toxoplasma gondi in adult mammalian macrophages cultivated in vitro. Proc Soc Exp Biol Med. 1954 Jul;86(3):413–419. doi: 10.3181/00379727-86-21117. [DOI] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES