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. 1968 Feb;14(2):273–284.

Mechanism of induction of immunological tolerance

IV. The effects of ultra-low doses of flagellin*

G R Shellam, G J V Nossal
PMCID: PMC1409291  PMID: 5640947

Abstract

Minute amounts of Salmonella adelaide flagellin were shown to be capable of inducing tolerance in newborn Wistar rats. With the range of doses, 10-9–10-1 μg, the following results were obtained:

(1) Tolerance could be induced in two zones of dosage by daily injections of flagellin during the first 2 weeks of life. The low zone corresponded to a dose of 10-7 μg/g body weight and the high zone to 10-3 μg/g body weight. Doses between these evoked an immune response.

(2) Daily injections of flagellin for 6 weeks resulted in a shift in the dosage required for low zone tolerance from 10-7 μg/g body weight to 10-5 μg/g body weight.

(3) The events of low zone tolerance occurred at an antigen concentration, which, in an organ such as the spleen of a newborn rat, never exceeded about 10-14 M. The high zone of tolerance corresponded to an antigen concentration of about 10-10 M.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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