Abstract
Rabbits rendered immunologically tolerant to BSA produced antibodies capable of precipitating BSA following immunization with DNP—BSA. Antigen binding studies using purified `anti-BSA' antibodies produced by tolerant animals indicated that these antibodies bound DNP—BSA with far greater avidity than BSA. It was concluded that a true termination of tolerance had not occurred. The implications of the results with regard to induction of antibody formation and of tolerance are discussed.
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