Skip to main content
NCBI home page
Immunology logoLink to Immunology
. 1968 May;14(5):611–619.

Ontogeny of cells producing haemolytic antibody or immunocyto-adherance to sheep erythrocytes in the chicken

J B Solomon
PMCID: PMC1409406  PMID: 5656874

Abstract

Spleen cell populations producing haemolytic antibody or exhibiting immunocyto-adherence (ICA) to sheep erythrocytes have been studied during ontogeny of the chicken. The proportion of ICA cells in spleens of immunized chickens increased steadily from 1 to 12 weeks of age. In immunized adults, as many as 8 per cent of spleen cells exhibited ICA; this was only ten times the number of similarly active cells in unimmunized adults. In immunized chickens, only a comparatively minor population of spleen cells were engaged in producing haemolytic antibody. There was a sudden increase in plaque-forming cells during 8–10 days after hatching but no further increase in the proportion of such cells during the remainder of development. It is suggested that immunological maturation in the normal animal may be due to cumulative antigenic experience during the first few months of development. Immunological maturation is expressed as an increase in the size of the pool of immunologically competent cells. Increases in population of antibody-forming cells from this pool may occur at different stages in ontogeny according to the type of immunity elicited by antigen.

Full text

PDF
611

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BENSON H. N., BRUMFIELD H. P., POMEROY B. S. Requirement of avian C'1 for fixation of guinea pig complement by avian antibody-antigen complexes. J Immunol. 1961 Nov;87:616–622. [PubMed] [Google Scholar]
  2. Baker P. J., Bernstein M., Pasanen V., Landy M. Detection and enumeration of antibody-producing cells by specific adherence of antigen-coated bentonite particles. J Immunol. 1966 Dec;97(6):767–777. [PubMed] [Google Scholar]
  3. Dent P. B., Good R. A. Absence of antibody production in the bursa of Fabricius. Nature. 1965 Jul 31;207(996):491–493. doi: 10.1038/207491a0. [DOI] [PubMed] [Google Scholar]
  4. MAEKELAE O. STUDIES ON THE QUALITY OF NEUTRALIZING BACTERIOPHAGE ANTIBODIES PRODUCED BY SINGLE CELLS. II. EVIDENCE INDICATING THAT DIFFERENT CELLS OF A LYMPH NODE PRODUCE DIFFERENT KINDS OF ANTIBODY AGAINST THE POLYSACCHARIDE ANTIGEN O-9,12 OF SALMONELLA. Immunology. 1964 Jan;7:17–25. [PMC free article] [PubMed] [Google Scholar]
  5. MAKELA O., NOSSAL G. J. Bacterial adherence: a method for detecting antibody production by single cells. J Immunol. 1961 Oct;87:447–456. [PubMed] [Google Scholar]
  6. MARTINS A. B., MOORE W. D., DICKINSON J. B., RAFFEL S. CELLULAR ACTIVITIES IN HYPERSENSITIVE REACTIONS. 3. SPECIFICALLY REACTIVE CELLS IN DELAYED HYPERSENSITIVITY: TUBERCULIN HYPERSENSITIVITY. J Immunol. 1964 Dec;93:953–959. [PubMed] [Google Scholar]
  7. MCDERMID E. M. IMMUNOGENETICS OF THE CHICKEN. A REVIEW. Vox Sang. 1964 May-Jun;9:249–267. doi: 10.1111/j.1423-0410.1964.tb02615.x. [DOI] [PubMed] [Google Scholar]
  8. Makinodan T., Albright J. F. Proliferative and differentiative manifestations of cellular immune potential. Prog Allergy. 1967;10:1–36. [PubMed] [Google Scholar]
  9. NOTA N. R., LIACOPOULOS-BRIOT M., STIFFEL C., BIOZZI G. L'IMMUNO-CYTO-ADH'ERENCE: UNE M'ETHODE SIMPLE ET QUANTITATIVE POUR L'ETUDE IN VITRO DES CELLULES PRODUCTRICES D'ANTICORPS. C R Hebd Seances Acad Sci. 1964 Aug 3;259:1277–1280. [PubMed] [Google Scholar]
  10. Nelson D. S., Mildenhall P. Studies on cytophilic antibodies. 1. The production by mice of macrophage cytophilic antibodies to sheep erythrocytes: relationship to the production of other antibodies and the development of delayed-type hypersensitivity. Aust J Exp Biol Med Sci. 1967 Apr;45(2):113–130. [PubMed] [Google Scholar]
  11. Solomon J. B. The appearance and nature of opsonins for goat erythrocytes during the development of the chicken. Immunology. 1966 Aug;11(2):79–87. [PMC free article] [PubMed] [Google Scholar]
  12. WELLER T. H., ENDERS J. F., ROBBINS F. C., STODDARD M. B. Studies on the cultivation of poliomyelitis viruses in tissue culture. I. The propagation of poliomyelitis viruses in suspended cell cultures of various human tissues. J Immunol. 1952 Dec;69(6):645–671. [PubMed] [Google Scholar]
  13. ZAALBERG O. B. A SIMPLE METHOD FOR DETECTING SINGLE ANTIBODY-FORMING CELLS. Nature. 1964 Jun 20;202:1231–1231. doi: 10.1038/2021231a0. [DOI] [PubMed] [Google Scholar]
  14. Zaalberg O. B., van der Meul V. A., van Twisk J. M. Antibody production by single spleen cells: a comparative study of the cluster and agar-plaque formation. Nature. 1966 Apr 30;210(5035):544–545. doi: 10.1038/210544a0. [DOI] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES