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. 1968 Nov;15(5):743–749.

The mechanism of anaphylactic histamine release from rabbit leucocytes

M W Greaves, J L Mongar
PMCID: PMC1409537  PMID: 4177078

Abstract

Histamine release from rabbit leucocytes is temperature-dependent and requires the presence of calcium but not magnesium ions. It is inhibited by agents which reduce disulphide linkages, and by sulphydryl-blocking agents, but potentiated by certain dicarboxylic acids.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AUSTEN K. F., BROCKLEHURST W. E. Anaphylaxis in chopped guinea pig lung. II. Enhancement of the anaphylactic release of histamine and slow reacting substance by certain dibasic aliphatic acids and inhibition by monobasic fatty acids. J Exp Med. 1961 Mar 1;113:541–557. doi: 10.1084/jem.113.3.541. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. EDMAN K. A., MONGAR J. L., SCHILD H. O. THE ROLE OF SH AND S-S GROUPS AND OXYGEN IN THE ANAPHYLACTIC REACTION OF CHOPPED GUINEA-PIG LUNG. J Physiol. 1964 Jan;170:124–137. doi: 10.1113/jphysiol.1964.sp007318. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Greaves M. W., Mongar J. L. The histamine content of rabbit leucocytes and its release during in vitro anaphylaxis. Immunology. 1968 Nov;15(5):733–742. [PMC free article] [PubMed] [Google Scholar]
  4. LICHTENSTEIN L. M., OSLER A. G. STUDIES ON THE MECHANISMS OF HYPERSENSITIVITY PHENOMENA. IX. HISTAMINE RELEASE FROM HUMAN LEUKOCYTES BY RAGWEED POLLEN ANTIGEN. J Exp Med. 1964 Oct 1;120:507–530. doi: 10.1084/jem.120.4.507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. MONGAR J. L., SCHILD H. O. Effect of temperature on the anaphylactic reaction. J Physiol. 1957 Feb 15;135(2):320–338. doi: 10.1113/jphysiol.1957.sp005713. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. MONGAR J. L., SCHILD H. O. Inhibition of histamine release in anaphylaxis. Nature. 1955 Jul 23;176(4473):163–163. doi: 10.1038/176163b0. [DOI] [PubMed] [Google Scholar]
  7. MONGAR J. L., SCHILD H. O. Inhibition of the anaphylactic reaction. J Physiol. 1957 Feb 15;135(2):301–319. doi: 10.1113/jphysiol.1957.sp005712. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. MONGAR J. L., SCHILD H. O. The effect of calcium and pH on the anaphylactic reaction. J Physiol. 1958 Feb 17;140(2):272–284. doi: 10.1113/jphysiol.1958.sp005933. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Perera B. A., Mongar J. L. Effect of anoxia, glucose and thioglycollate on anaphylactic and compound 48/80-induced histamine release in isolated rat mast cells. Immunology. 1965 May;8(5):519–525. [PMC free article] [PubMed] [Google Scholar]
  10. UVNAS B., THON I. L. Evidence for enzymatic histamine release from isolated rat mast cells. Exp Cell Res. 1961 Feb;23:45–57. doi: 10.1016/0014-4827(61)90062-3. [DOI] [PubMed] [Google Scholar]

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