Skip to main content
NCBI home page
Immunology logoLink to Immunology
. 1969 May;16(5):669–676.

Soluble TL and H-2 antigens prepared from a TL positive leukaemia of a TL negative mouse strain

D A L Davies, Barbara J Alkins, E A Boyse, L J Old, Elizabeth Stockert
PMCID: PMC1409592  PMID: 5787772

Abstract

TL (thymus-leukaemia) antigens are specified by the TLa locus, which is closely linked to H-2, the locus responsible for the major transplantation antigens of the mouse. Unlike other non-H-2 antigens tested for, TL antigens did not separate from H-2 antigens through a series of purification steps. On DEAE ion exchange chromatography, however, certain H-2 antigens tested for were separated from one another, and TL antigens occupied a different position between them. Thus the properties of TL antigens that appear by gene activation consequent upon leukaemogenesis in TL negative mice are not distinguishable from the properties of TL antigens occurring as a normal feature of TL positive mice.

Full text

PDF
669

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boyse E. A., Miyazawa M., Aoki T., Old L. J. Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse. Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(1019):175–193. doi: 10.1098/rspb.1968.0032. [DOI] [PubMed] [Google Scholar]
  2. Boyse E. A., Old L. J., Stockert E. An approach to the mapping of antigens on the cell surface. Proc Natl Acad Sci U S A. 1968 Jul;60(3):886–893. doi: 10.1073/pnas.60.3.886. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Boyse E. A., Old L. J., Stockert E., Shigeno N. Genetic origin of tumor antigens. Cancer Res. 1968 Jul;28(7):1280–1287. [PubMed] [Google Scholar]
  4. Boyse E. A., Stockert E., Old L. J. Modification of the antigenic structure of the cell membrane by thymus-leukemia (TL) antibody. Proc Natl Acad Sci U S A. 1967 Sep;58(3):954–957. doi: 10.1073/pnas.58.3.954. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Davies D. A., Manstone A. J., Viza D. C., Colombani J., Dausset J. Human transplantation antigens: the HL-A (Hu-1) system and its homology with the mouse H-2 system. Transplantation. 1968 Jul;6(4):571–586. [PubMed] [Google Scholar]
  6. Davies D. A. Mouse histocompatibility isoantigens derived from normal and from tumour cells. Immunology. 1966 Aug;11(2):115–125. [PMC free article] [PubMed] [Google Scholar]
  7. Nathenson S. G., Davies D. A. Solubilization and partial purification of mouse histocompatibility antigens from a membranous lipoprotein fraction. Proc Natl Acad Sci U S A. 1966 Aug;56(2):476–483. doi: 10.1073/pnas.56.2.476. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. REIF A. E., ALLEN J. M. THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES. J Exp Med. 1964 Sep 1;120:413–433. doi: 10.1084/jem.120.3.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Shimada A., Nathenson S. G. Solubilization of membrane H-2 isoantigens: chromatographic separation of specificities determined by a single H-2 genotype. Biochem Biophys Res Commun. 1967 Dec 29;29(6):828–833. doi: 10.1016/0006-291x(67)90294-x. [DOI] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES