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. 1969 Mar;16(3):293–299.

A quantitative study of the transfer of colostral immunoglobulins to the newborn calf

G G B Klaus, Ann Bennett, E W Jones
PMCID: PMC1409623  PMID: 5770381

Abstract

The transfer of colostral IgM and IgG to newborn calves was studied quantitatively. Both IgM and IgG were absorbed equally well from the gastrointestinal tract of the calf. However, the degree of globulin absorption and hence the serum immunoglobulin concentrations varied considerably from calf to calf. Three of the ten calves remained virtually agammaglobulinaemic despite the ingestion of colostrum. The significance of failure to absorb colostral immunoglobulins (especially IgM) is discussed in relation to the pathogenesis of neonatal septicaemias of the newborn calf.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DIXON F. J., WEIGLE W. O., VAZQUEZ J. J. Metabolism and mammary secretion of serum proteins in the cow. Lab Invest. 1961 Mar-Apr;10:216–237. [PubMed] [Google Scholar]
  2. Ellis E. F., Smith R. T. The role of the spleen in immunity. With special reference to the post-splenectomy problem in infants. Pediatrics. 1966 Jan;37(1):111–119. [PubMed] [Google Scholar]
  3. FEY H., MARGADANT A. [Hypogammaglobulinemia in coli sepsis in the calf]. Pathol Microbiol (Basel) 1961;24:970–976. [PubMed] [Google Scholar]
  4. FREDA V. J. Placental transfer of antibodies in man. Am J Obstet Gynecol. 1962 Dec 1;84:1756–1777. doi: 10.1016/0002-9378(62)90015-7. [DOI] [PubMed] [Google Scholar]
  5. Hill W. C., Robbins J. B. Horse anti-pneumococcal immunoglobulins. II. Specific mouse protective activity. Proc Soc Exp Biol Med. 1966 Oct;123(1):105–108. doi: 10.3181/00379727-123-31414. [DOI] [PubMed] [Google Scholar]
  6. Klaus G. G., Jones E. W. The immunoglobulin response in intact and splenectomized calves infected with Anaplasma marginale. J Immunol. 1968 May;100(5):991–999. [PubMed] [Google Scholar]
  7. LOCKE R. F., MYERS W. L., SEGRE D. THE IMMUNOLOGIC BEHAVIOR OF BABY PIGS. IV. INTESTINAL ABSORPTION AND PERSISTANCE OF 6.6S AND 18S ANTIBODIES OF OVINE ORIGIN AND THEIR ROLE IN THE IMMUNOLOGIC COMPETENCE OF BABY PIGS. J Immunol. 1964 Oct;93:576–583. [PubMed] [Google Scholar]
  8. LOSPALLUTO J., MILLER W., Jr, DORWARD B., FINK C. W. The formation of macroglobulin antibodies. I. Studies on adult humans. J Clin Invest. 1962 Jul;41:1415–1421. doi: 10.1172/JCI104596. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lecce J. G. Absorption of macromolecules by neonatal intestine. Biol Neonat. 1965;9(1):50–61. [PubMed] [Google Scholar]
  10. MURPHY F. A., AALUND O., OSEBOLD J. W., CARROLL E. J. GAMMA GLOBULINS OF BOVINE LACTEAL SECRETIONS. Arch Biochem Biophys. 1964 Nov;108:230–239. doi: 10.1016/0003-9861(64)90380-7. [DOI] [PubMed] [Google Scholar]
  11. PIERCE A. E. Electrophoretic and immunological studies on sera from calves from birth to weaning. I. Electrophoretic studies. J Hyg (Lond) 1955 Sep;53(3):247–260. doi: 10.1017/s0022172400000747. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. PIERCE A. E., FEINSTEIN A. BIOPHYSICAL AND IMMUNOLOGICAL STUDIES ON BOVINE IMMUNE GLOBULINS WITH EVIDENCE FOR SELECTIVE TRANSPORT WITHIN THE MAMMARY GLAND FROM MATERNAL PLASMA TO COLOSTRUM. Immunology. 1965 Jan;8:106–123. [PMC free article] [PubMed] [Google Scholar]
  13. PIKE R. M., SCHULZE M. L. PRODUCTION OF 7S AND 19S ANTIBODIES TO THE SOMATIC ANTIGENS OF SALMONELLA TYPHOSA IN RABBITS. Proc Soc Exp Biol Med. 1964 Mar;115:829–833. doi: 10.3181/00379727-115-29050. [DOI] [PubMed] [Google Scholar]
  14. ROBBINS J. B., KENNY K., SUTER E. THE ISOLATION AND BIOLOGICAL ACTIVITIES OF RABBIT GAMMA M- AND GAMMA G-ANTI-SALMONELLA TYPHIMURIUM ANTIBODIES. J Exp Med. 1965 Aug 1;122:385–402. doi: 10.1084/jem.122.2.385. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. SMITH H. W. Observations on the aetiology of neonatal diarrhoea (scours) in calves. J Pathol Bacteriol. 1962 Jul;84:147–168. [PubMed] [Google Scholar]
  16. Smith H. W., Simmons E. J., O'Neil J. A. The immune globulin content of the serum of calves in England. Vet Rec. 1967 Jun 10;80(23):664–666. doi: 10.1136/vr.80.23.664. [DOI] [PubMed] [Google Scholar]
  17. WEIDANZ W. P., JACKSON A. L., LANDY M. SOME ASPECTS OF THE ANTIBODY RESPONSE OF RABBITS TO IMMUNIZATION WITH ENTEROBACTERIAL SOMATIC ANTIGENS. Proc Soc Exp Biol Med. 1964 Jul;116:832–837. doi: 10.3181/00379727-116-29386. [DOI] [PubMed] [Google Scholar]
  18. van Furth R., Schuit H. R., Hijmans W. The immunological development of the human fetus. J Exp Med. 1965 Dec 1;122(6):1173–1188. doi: 10.1084/jem.122.6.1173. [DOI] [PMC free article] [PubMed] [Google Scholar]

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