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. 1975 Apr;16(4):272–276. doi: 10.1136/gut.16.4.272

The effect of intravenous infusions of prostaglandins E-2 and F-2alpha on human gastric function.

A Newman, J P de Moraes-Filho, D Philippakos, J J Misiewicz
PMCID: PMC1410922  PMID: 1132802

Abstract

The effect of intravenous infusions of prostaglandins E-2 and F(-2alpha) at various dose levels on basal, or on maximally or submaximally pentagastrin-stimulated acid secretion, was studied in 40 male subjects. Intraluminal antral pressures were also measured. Prostaglandin F (0.08 mug kg-minus 1 min-minus 1) transiently, but significantly, inhibited submaximal acid output and increased the frequency of antral contractions. Prostaglandin E(2)(0.08 mug kg-minus 1 min-minus 1) inhibited basal acid secretion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett A., Eley K. G., Scholes G. B. Effects of prostaglandins E1 and E2 on human, guinea-pig and rat isolated small intestine. Br J Pharmacol. 1968 Nov;34(3):630–638. doi: 10.1111/j.1476-5381.1968.tb08492.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bennett A., Murray J. G., Wyllie J. H. Occurrence of prostaglandin E2 in the human stomach, and a study of its effects on human isolated gastric muscle. Br J Pharmacol Chemother. 1968;32:339–349. [PMC free article] [PubMed] [Google Scholar]
  3. Bennett A., Posner J. Studies on prostaglandin antagonists. Br J Pharmacol. 1971 Aug;42(4):584–594. doi: 10.1111/j.1476-5381.1971.tb07142.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bennett A., Stamford I. F., Unger W. G. Prostaglandin E2 and gastric acid secretion in man. J Physiol. 1973 Mar;229(2):349–360. doi: 10.1113/jphysiol.1973.sp010142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bickel J. G., Witten T. A., Killian M. K. Use of pertechnetate clearance in the study of gastric physiology. Gastroenterology. 1972 Jul;63(1):60–66. [PubMed] [Google Scholar]
  6. Classen M., Koch H., Deyhle P., Weidenhiller S., Demling L. Wirkung von Prostaglandin E 1 auf die basale Magensekretion des Menschen. Klin Wochenschr. 1970 Jul 15;48(14):876–878. doi: 10.1007/BF01583910. [DOI] [PubMed] [Google Scholar]
  7. Classen M., Stürzenhofecker P., Koch H., Demling L. The effect of prostaglandin E1 on the secretion and the motility of the human stomach. Acta Hepatogastroenterol (Stuttg) 1973 Mar-Apr;20(2):159–162. [PubMed] [Google Scholar]
  8. Cummings J. H., Newman A., Misiewicz J. J., Milton-Thompson G. J., Billings J. A. Effect of intravenous prostaglandin F 2 on small intestinal function in man. Nature. 1973 May 18;243(5403):169–171. doi: 10.1038/243169a0. [DOI] [PubMed] [Google Scholar]
  9. Dilawari J. B., Newman A., Poleo J., Misiewicz J. J. Response of the human cardia sphincter to circulating prostaglandins F2ALPHA and E2 and to antiinflammatory drugs. Gut. 1975 Feb;16(2):137–143. doi: 10.1136/gut.16.2.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. HORTON E. W., MAIN I. H. A COMPARISON OF THE ACTIONS OF PROSTAGLANDINS F2-ALPHA AND E1 ON SMOOTH MUSCLE. Br J Pharmacol Chemother. 1965 Apr;24:470–476. doi: 10.1111/j.1476-5381.1965.tb01736.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hollenberg M., Walker R. S., McCormick D. P. Cardiovascular responses to intracoronary infusion of prostaglandin E-1, F-1 alpha and F-2 alpha. Arch Int Pharmacodyn Ther. 1968 Jul;174(1):66–73. [PubMed] [Google Scholar]
  12. Jacobson E. D. Comparison of prostaglandin E1 and norepinephrine on the gastric mucosal circulation. Proc Soc Exp Biol Med. 1970 Feb;133(2):516–519. doi: 10.3181/00379727-133-34509. [DOI] [PubMed] [Google Scholar]
  13. Kwong N. K., Brown B. H., Whittaker G. E., Duthie H. L. Response of the electrical activity, motor activity and acid secretion of the human stomach to pentagastrin and histamine stimulation. Scand J Gastroenterol. 1971;6(2):145–153. doi: 10.3109/00365527109180684. [DOI] [PubMed] [Google Scholar]
  14. Misiewicz J. J., Holdstock D. J., Waller S. L. Motor responses of the human alimentary tract to near-maximal infusions of pentagastrin. Gut. 1967 Oct;8(5):463–469. doi: 10.1136/gut.8.5.463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Nezamis J. E., Robert A., Stowe D. F. Inhibition by prostaglandin E 1 of gastric secretion in the dog. J Physiol. 1971 Oct;218(2):369–383. doi: 10.1113/jphysiol.1971.sp009623. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Raz A. Interaction of prostaglandins with blood plasma proteins. I. Binding of prostaglandin E 2 to human plasma proteins and its effect on the physiological activity of prostaglandin E 2 in vitro and in vivo. Biochim Biophys Acta. 1972 Dec 8;280(4):602–613. [PubMed] [Google Scholar]
  17. Robert A., Nezamis J. E., Phillips J. P. Inhibition of gastric secretion by prostaglandins. Am J Dig Dis. 1967 Oct;12(10):1073–1076. doi: 10.1007/BF02233268. [DOI] [PubMed] [Google Scholar]
  18. STEINBERG D., VAUGHAN M., NESTEL P. J., STRAND O., BERGSTROEM S. EFFECTS OF THE PROSTAGLANDINS ON HORMONE-INDUCED MOBILIZATION OF FREE FATTY ACIDS. J Clin Invest. 1964 Aug;43:1533–1540. doi: 10.1172/JCI105030. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Way L., Durbin R. P. Inhibition of gastric acid secretion in vitro by prostaglandin E1. Nature. 1969 Mar 1;221(5183):874–875. doi: 10.1038/221874a0. [DOI] [PubMed] [Google Scholar]
  20. Weeks J. R., Sekhar N. C., Ducharme D. W. Relative activity of prostaglandins E1, A1, E2 and A2 on lipolysis, platelet aggregation, smooth muscle and the cardiovascular system. J Pharm Pharmacol. 1969 Feb;21(2):103–108. doi: 10.1111/j.2042-7158.1969.tb08205.x. [DOI] [PubMed] [Google Scholar]
  21. Wilson D. E., Levine R. A. The effect of prostaglandin E 1 on canine gastric acid secretion and gastric mucosal blood flow. Am J Dig Dis. 1972 Jun;17(6):527–532. doi: 10.1007/BF02231209. [DOI] [PubMed] [Google Scholar]

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