Skip to main content
PMC home page
Gut logoLink to Gut
. 1975 Jan;16(1):47–49. doi: 10.1136/gut.16.1.47

The effect of intravenous prostaglandin F2 alpha and E2 on the motility of the sigmoid colon.

R H Hunt, J B Dilawari, J J Misiewicz
PMCID: PMC1410933  PMID: 1140625

Abstract

The effect of a 20-min intravenous infusion of prostaglandin E2 (0-08 mug kg-1 min-1) or of prostaglandin F2 alpha (0-8 mug kg-1 min-1) on the segmental pressures in the sigmoid colon was studied in 12 patients. Prostaglandin F2 alpha had no measurable effect, but prostaglandin E2 significantly inhibited sigmoid motility.

Full text

PDF
47

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett A., Posner J. Studies on prostaglandin antagonists. Br J Pharmacol. 1971 Aug;42(4):584–594. doi: 10.1111/j.1476-5381.1971.tb07142.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cummings J. H., James W. P., Wiggins H. S. Role of the colon in ileal-resection diarrhoea. Lancet. 1973 Feb 17;1(7799):344–347. doi: 10.1016/s0140-6736(73)90131-1. [DOI] [PubMed] [Google Scholar]
  3. Cummings J. H., Newman A., Misiewicz J. J., Milton-Thompson G. J., Billings J. A. Effect of intravenous prostaglandin F 2 on small intestinal function in man. Nature. 1973 May 18;243(5403):169–171. doi: 10.1038/243169a0. [DOI] [PubMed] [Google Scholar]
  4. Harvey R. F., Read A. E. Effect of cholecystokinin on colonic motility and symptoms in patients with the irritable-bowel syndrome. Lancet. 1973 Jan 6;1(7793):1–3. doi: 10.1016/s0140-6736(73)91219-1. [DOI] [PubMed] [Google Scholar]
  5. Harvey R. F., Read A. E. Saline purgatives act by releasing cholecystokinin. Lancet. 1973 Jul;2(7822):185–187. doi: 10.1016/s0140-6736(73)93011-0. [DOI] [PubMed] [Google Scholar]
  6. Matuchansky C., Bernier J. J. Effect of prostaglandin E 1 on glucose, water, and electrolyte absorption in the human jejunum. Gastroenterology. 1973 Jun;64(6):1111–1118. [PubMed] [Google Scholar]
  7. Milton-Thompson G. J., Cummings J. H., Newman A., Billings J. A., Misiewicz J. J. Colonic and small intestinal response to intravenous prostaglandin F2 alpha and E2 in man. Gut. 1975 Jan;16(1):42–46. doi: 10.1136/gut.16.1.42. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Misiewicz J. J., Connell A. M., Pontes F. A. Comparison of the effect of meals and prostigmine on the proximal and distal colon in patients with and without diarrhoea. Gut. 1966 Oct;7(5):468–473. doi: 10.1136/gut.7.5.468. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Misiewicz J. J., Waller S. L., Kiley N. Effect of oral prostaglandin E1 on intestinal transit in man. Lancet. 1969 Mar 29;1(7596):648–651. doi: 10.1016/s0140-6736(69)92012-1. [DOI] [PubMed] [Google Scholar]
  10. Pierce N. F., Carpenter C. C., Jr, Elliott H. L., Greenough W. B., 3rd Effects of prostaglandins, theophylline, and cholera exotoxin upon transmucosal water and electrolyte movement in the canine jejunum. Gastroenterology. 1971 Jan;60(1):22–32. [PubMed] [Google Scholar]
  11. Sandler M., Karim S. M., Williams E. D. Prostaglandins in amine-peptide-secreting tumours. Lancet. 1968 Nov 16;2(7577):1053–1054. doi: 10.1016/s0140-6736(68)91528-6. [DOI] [PubMed] [Google Scholar]
  12. Waller S. L., Misiewicz J. J., Kiley N. Effect of eating on motility of the pelvic colon in constipation or diarrhoea. Gut. 1972 Oct;13(10):805–811. doi: 10.1136/gut.13.10.805. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Waller S. L. Proceedings: Differential measurement of small and large bowel transit. Gut. 1973 Oct;14(10):817–817. [PubMed] [Google Scholar]
  14. Williams E. D., Karim S. M., Sandler M. Prostaglandin secretion by medullary carcinoma of the thyroid. A possible cause of the associated idarrhoea. Lancet. 1968 Jan 6;1(7532):22–23. doi: 10.1016/s0140-6736(68)90010-x. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES